Does Coenzyme Q10 Plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?
Castro-Marrero, Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Domingo, Joan Carles (Universitat de Barcelona)
Cordobilla, Begoña (Universitat de Barcelona)
Ferrer Costa, Roser (Hospital Universitari Vall d'Hebron)
Giralt Arnaiz, Marina (Hospital Universitari Vall d'Hebron)
Sanmartin Sentañes, Ramon (Hospital Universitari Vall d'Hebron)
Alegre Martín, José (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona
Data: |
2022 |
Resum: |
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a neuroinflammatory, multifaceted chronic disorder of unknown cause. Accumulating data indicate a link between a redox imbalance, mitochondrial dysfunction, and inflammation status in ME/CFS. Coenzyme Q10 (CoQ10) and selenium as effective antioxidant and anti-inflammatory agents have shown potential clinical implications in chronic diseases; however, their therapeutic benefits in ME/CFS remain elusive. This open-label exploratory study aimed to evaluate the effectiveness of combined CoQ10 plus selenium supplementation on clinical features and circulating biomarkers in ME/CFS. Twenty-seven ME/CFS patients received an oral combination of 400 mg of CoQ10 and 200 μg of selenium daily for 8 weeks. The primary endpoint was patient-reported changes in outcome measures from baseline to 8 weeks' postintervention. Secondary endpoint included changes in circulating biomarkers from baseline to each participant. After an 8-week intervention, a significant improvement was found for overall fatigue severity (p = 0. 021) and global quality of life (p = 0. 002), while there was no significant effect on the sleep disturbances (p = 0. 480) among participants. After 8 week's intervention, there was significantly increased total antioxidant capacity, and there were reduced lipoperoxide levels from the participants (p < 0. 0001 for both). Circulating cytokine levels decreased significantly (p < 0. 01 for all), but with no significant changes in the C-reactive protein, FGF21, and NT-proBNP biomarkers after supplementation. Based on these findings, we hypothesized that long-term supplementation of combined CoQ10 and selenium may indicate a potentially beneficial synergistic effect in ME/CFS. Antioxid. Redox Signal. 36, 729-739. |
Drets: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Matèria: |
Biomarkers ;
Cardiovascular health ;
Chronic fatigue syndrome ;
Coenzyme Q10 ;
Inflammation ;
Myalgic encephalomyelitis ;
Redox status ;
Selenium |
Publicat a: |
Antioxidants & Redox Signaling, Vol. 36 (april 2022) , p. 729-739, ISSN 1557-7716 |
DOI: 10.1089/ars.2022.0018
PMID: 35229657
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