Fine Control of In Vivo Magnetic Hyperthermia Using Iron Oxide Nanoparticles with Different Coatings and Degree of Aggregation
Luengo, Yurena (IMDEA Nanociencia)
Díaz Riascos, Zamira Vanessa (Vall d'Hebron Institut de Recerca (VHIR))
García-Soriano, David (IMDEA Nanociencia)
Teran, Francisco J. (Centro Nacional de Biotecnología)
Artés-Ibáñez, Emilio J. (IMDEA Nanociencia)
Ibarrola, Oihane (Biokeralty Research Institute AIE)
Somoza, Álvaro (Centro Nacional de Biotecnología)
Miranda, Rodolfo (Centro Nacional de Biotecnología)
Schwartz, Simon (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Abasolo, Ibane (Vall d'Hebron Institut de Recerca (VHIR))
Salas, Gorka (Centro Nacional de Biotecnología)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	The clinical implementation of magnetic hyperthermia has experienced little progress since the first clinical trial was completed in 2005. Some of the hurdles to overcome are the reliable production of magnetic nanoparticles with controlled properties and the control of the temperature at the target tissue in vivo. Here, forty samples of iron oxide superparamagnetic nanoparticles were prepared by similar methods and thoroughly characterized in terms of size, aggregation degree, and heating response. Selected samples were intratumorally administered in animals with subcutaneous xenografts of human pancreatic cancer. In vivo experiments showed that it is possible to control the rise in temperature by modulating the field intensity during in vivo magnetic hyperthermia protocols. The procedure does not require sophisticated materials and it can be easily implemented by researchers or practitioners working in magnetic hyperthermia therapies.
Grants:	Agencia Estatal de Investigación PID2019-106301RB-I00
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cancer ; Controlled heat in vivo ; Magnetic hyperthermia ; Nanoparticles
Published in:	Pharmaceutics, Vol. 14 Núm. 8 (august 2022) , p. 1526, ISSN 1999-4923

DOI: 10.3390/pharmaceutics14081526
PMID: 35893782

15 p, 2.6 MB

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