DMEK for the treatment of interface fluid syndrome secondary to failed DSAEK graft : A case report and review of the literature
Moura-Coelho, Nuno (Escola Superior de Tecnologias da Saúde de Lisboa (ESTeSL) - Instituto Politécnico de Lisboa)
Arrondo, Elena (European School for Advanced Studies in Ophthalmology (ESASO). Villa Saroli (Suïssa))
Papa-Vettorazzi, Mario Renato (Instituto Microcirurgia Ocular (IMO) Barcelona Grupo Miranza)
Cunha, João Paulo (Hospital CUF Cascais (Lisboa, Portugal))
Güell, Jose (Universitat Autònoma de Barcelona)

Data:	2022
Resum:	To report a case of Descemet membrane endothelial keratoplasty (DMEK) for the management of post-laser in situ keratomileusis (LASIK) interface fluid syndrome (IFS) secondary to failed Descemet stripping automated endothelial keratoplasty (DSAEK) graft, and to provide a literature review on endothelial keratoplasty (EK) for this indication. A 52-year-old patient presented with LASIK interface fluid accumulation and a non-functioning primary DSAEK graft. Past ophthalmic history was relevant for: (1) phakic intraocular lens (PIOL) implantation with later refinement by LASIK; (2) combined PIOL explantation and refractive lens exchange due to accelerated endothelial cell loss (ECL); (3) primary DSAEK due to corneal decompensation. A secondary EK graft (DMEK) was performed, and the patient was prospectively followed for 6 months (M6). DMEK surgery was uneventful, without postoperative graft detachment. Corneal clearing and resolution of interface fluid accumulation occurred during the first postoperative month. Best-corrected visual acuity (BCVA) improved from 20/800 Snellen to 20/25 Snellen at 3-month follow-up, remaining stable at M6. Due to a persistent rise in intraocular pressure (IOP), the patient underwent uneventful non-penetrating deep sclerectomy 2 months after DMEK, with controlled IOP and without accelerated ECL. DMEK is feasible, effective, and safe in the management of IFS in cases where corneal endothelial failure plays a major role, even in complex eyes with previous EK grafts. Aggressive postoperative IOP control is warranted to decrease the risk of interface fluid recurrence and damage to the optic nerve. Studies with larger patient numbers are encouraged to ascertain the role of EK for this indication.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	DMEK ; DMEK, Descemet membrane endothelial keratoplasty ; Descemet membrane endothelial keratoplasty ; Endothelial keratoplasty ; IOP ; Intraocular pressure ; Interface fluid syndrome ; LASIK ; LASIK, LASER in situ keratomileusis ; Laser in situ keratomileusis
Publicat a:	American Journal of Ophthalmology Case Reports, Vol. 27 (september 2022) , p. 101656, ISSN 2451-9936

DOI: 10.1016/j.ajoc.2022.101656
PMID: 35865659

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