Risk of thrombotic events and other complications in anticoagulant users infected with SARS-CoV-2 : an observational cohort study in primary health care in SIDIAP (Catalonia, Spain)
Giner-Soriano, Maria (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Gomez-Lumbreras, Ainhoa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Vedia Urgell, Cristina (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Ouchi, Dan (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Morros, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)

Data:	2022
Resum:	The risk of thromboembolic events and COVID-19 complications in anticoagulated patients once hospitalized has been widely analyzed. We aim to assess these outcomes in primary health care (PHC) patients chronically treated with oral anticoagulants (OAC) in comparison with non-treated. Cohort study including adults with COVID-19 diagnosis in the PHC records in Catalonia, Spain; from March to June 2020. Patients were matched between exposed and non-exposed to OAC based on age and gender in a 1:2 design. Data source is the Information System for Research in Primary Care (SIDIAP). We included 311,542 individuals with COVID-19. After propensity score matching, we obtained a cohort of 20,360 people, 10,180 exposed and 10,180 non-exposed to OAC. Their mean age was 79. 9 and 52. 1% were women. Patients exposed to OAC had a higher frequency of comorbidities than non-exposed. Anticoagulated patients had a higher risk of hospital admission (IRR 1. 16, 95% CI 1. 03-1. 29), and of stroke and pulmonary embolism than non-anticoagulated (IRR 1,80, 95% CI 1. 06-3. 06). The risk of pneumonia was not different between groups (IRR 1. 04, 95% CI 0. 84-1. 30). We found a lower risk of death in patients exposed to OAC (IRR 0. 60, 95% CI 0. 55-0. 65). OAC users in our study had more comorbidities and were older than non-users, well known risks for hospitalization being confirmed with our results. We also found in our study that OAC exposure was not associated to an increased risk in the mortality rate, and it was associated with higher risks of hospital admission and thromboembolic events, although we cannot assess the effect of the interventions applied during hospital admission on the outcomes studied, as our database is a PHC database. EUPAS register: . The online version contains supplementary material available at 10. 1186/s12875-022-01752-5.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	COVID-19 ; Electronic health records ; Oral anticoagulants ; Primary health care ; Thrombotic events
Publicat a:	BMC Primary Care, Vol. 23 (june 2022) , ISSN 2731-4553

DOI: 10.1186/s12875-022-01752-5
PMID: 35676639

8 p, 829.2 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats