Bartonella Endocarditis in Spain : Case Reports of 21 Cases
García-Álvarez, Lara (Hospital San Pedro de Alcántara)
García-García, Concepción (Hospital San Pedro de Alcántara)
Munoz, Patricia (Universidad Complutense de Madrid)
Fariñas-Álvarez, María del Carmen (Universidad de Cantabria)
Cuadra, Manuel Gutiérrez (Universidad de Cantabria)
Fernández-Hidalgo, Nuria (Universitat Autònoma de Barcelona. Departament de Medicina)
García-Vázquez, Elisa (Universidad de Murcia)
Moral-Escudero, Encarnación (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Alonso-Socas, María del Mar (Hospital Universitario de Canarias (La Laguna))
García-Rosado, Dácil (Hospital Universitario de Canarias (La Laguna))
Hidalgo-Tenorio, Carmen (Hospital Universitario Virgen de las Nieves (Granada))
Domınguez, Fernando (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Goikoetxea, Josune (Hospital Universitario de Cruces (Barakaldo, País Basc))
Gainzarain, Juan Carlos (Arabako Unibertsitate Ospitalea (Vitoria, País Basc))
Rodríguez-Esteban, María Ángeles (Hospital Universitario Central de Asturias)
Bosch-Guerra, Xerach (Hospital Universitario de Gran Canaria Dr. Negrín)
Oteo, José A. (Hospital San Pedro de Alcántara)

Data:	2022
Resum:	Blood culture negative endocarditis (BCNE) is frequent in infective endocarditis (IE). One of the causes of BCNE is fastidious microorganisms, such as Bartonella spp. The aim of this study was to describe the epidemiologic, clinical characteristics, management and outcomes of patients with Bartonella IE from the "Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)"cohort. Here we presented 21 cases of Bartonella IE. This represents 0. 3% of a total of 5590 cases and 2% of the BCNE from the GAMES cohort. 62% were due to Bartonella henselae and 38% to Bartonella quintana. Cardiac failure was the main presenting form (61. 5% in B. hensalae, 87. 5% in B. quintana IE) and the aortic valve was affected in 85% of the cases (76% in B. henselae, 100% in B. quintana IE). Typical signs such as fever were recorded in less than 40% of patients. Echocardiography showed vegetations in 92% and 100% of the patients with B. henselae and B. quintana, respectively. Culture was positive only in one patient and the remaining were diagnosed by serology and PCR. PCR was the most useful tool allowing for diagnosis in 16 patients (100% of the studied valves). Serology, at titers recommended by guidelines, only coincided with PCR in 52. 4%. Antimicrobial therapy, in different combinations, was used in all cases. Surgery was performed in 76% of the patients. No in-hospital mortality was observed. One-year mortality was 9. 4%. This article remarks the importance for investigating the presence of Bartonella infection as causative agent in all BCNE since the diagnosis needs specific microbiological tools and patients could benefit of a specific treatment.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Infective endocarditis ; Blood culture negative endocarditis ; Bartonella endocarditis ; Bartonella spp
Publicat a:	Pathogens, Vol. 11 (may 2022) , ISSN 2076-0817

DOI: 10.3390/pathogens11050561
PMID: 35631082

14 p, 319.1 KB

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