First Identification of Reinfection by a Genetically Different Variant of SARS-CoV-2 in a Homeless Person from the Metropolitan Area of Santiago, Chile
Acuña-Castillo, Claudio (Universidad de Santiago de Chile. Departamento de Biología)
Vidal, Mabel (Universidad de Concepción)
Inostroza-Molina, Ailen (Universidad de Santiago de Chile)
Vallejos Vidal, Eva Carolina (Universidad de Las Américas)
Luraschi, Roberto (Universidad de Santiago de Chile)
Figueroa, Maximiliano (Universidad de Santiago de Chile)
Barrera-Avalos, Carlos (Universidad de Santiago de Chile)
Vera, Rodrigo (Hospital de Urgencia Asistencia Pública)
Vargas, Sergio (Hospital de Urgencia Asistencia Pública)
Valdes, Daniel (Universidad de Santiago de Chile. Departamento de Biología)
Maisey, Kevin (Universidad de Santiago de Chile)
Imarai, Mónica (Universidad de Santiago de Chile. Departamento de Biología)
Leiva-Salcedo, Elías (Universidad de Santiago de Chile)
Escobar, Alejandro (Universidad de Chile)
Reyes-Cerpa, Sebastián (Universidad Mayor)
Gaete, Alexis (Universidad de Chile)
Palma-Vejares, Ricardo (Universidad de Chile)
Travisany, Dante (Inria Chile Research Center)
Rojo, Leonel E. (Universidad de Santiago de Chile. Departamento de Biología)
Reyes-López, Felipe E. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Sandino, Ana María (Universidad de Santiago de Chile. Departamento de Biología)

Data:	2022
Resum:	The identification and tracking of SARS-CoV-2 infected patients in the general population are essential components of the global strategy to limit the COVID-19 viral spread, specifically for maintaining traceability and suppressing the resurgence of local outbreaks. Public health programs that include continuous RT-qPCR testing for COVID-19 in the general population, viral sequencing, and genomic surveillance for highly contagious forms of the virus have allowed for the identification of SARS-CoV-2 infections and reinfections. This work identified SARS-CoV-2 reinfection in a homeless person, which occurred 58 days after the first COVID-19 diagnosis. Genomic sequencing identified a different Nextstrain classification clade (20A and 20B) and PANGO lineage, with a divergence of 4 single nucleotide variants (SNVs) in S and ORF1ab genes, suggesting reinfection by different viral variants. This study is the first from the great metropolitan area of Santiago, Chile, one of the top ten countries in the world to live during the COVID-19 pandemic. We support the importance of performing intensive genomic surveillance programs in the whole population and high-risk groups, such as homeless people, nearly 20 thousand people in Chile, and have limited access to health care services and poor viral traceability.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Journal of Environmental and Public Health, Vol. 2022 (April 2022) , art. 3859071, ISSN 1687-9813

DOI: 10.1155/2022/3859071
PMID: 35528635

6 p, 704.7 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats