Integrating Dietary Data into Microbiome Studies : A Step Forward for Nutri-Metaomics
Yañez, Francisca (Universitat Autònoma de Barcelona. Departament de Medicina)
Soler, Zaida (Universitat Autònoma de Barcelona. Departament de Medicina)
Oliero, Manon (Vall d'Hebron Institut de Recerca (VHIR))
Xie, Zixuan (Universitat Autònoma de Barcelona. Departament de Medicina)
Oyarzun, Iñigo (Vall d'Hebron Institut de Recerca (VHIR))
Serrano-Gómez, Gerard (Vall d'Hebron Institut de Recerca (VHIR))
Manichanh, Chaysavanh (Vall d'Hebron Institut de Recerca (VHIR))

Data:	2021
Resum:	Diet is recognised as the main driver of changes in gut microbiota. However, linking habitual dietary intake to microbiome composition and activity remains a challenge, leaving most microbiome studies with little or no dietary information. To fill this knowledge gap, we conducted two consecutive studies (n = 84: a first pilot study (n = 40) to build a web-based, semi-quantitative simplified FFQ (sFFQ) based on three 24-h dietary recalls (24HRs); a second study (n = 44) served to validate the newly developed sFFQ using three 24HRs as reference method and to relate gut microbiome profiling (16S rRNA gene) with the extracted dietary and lifestyle data. Relative validation analysis provided acceptable classification and agreement for 13 out of 24 (54%) food groups and 20 out of 29 nutrients (69%) based on intraclass correlation coefficient, cross-classification, Spearman's correlation, Wilcoxon test, and Bland-Altman. Microbiome analysis showed that higher diversity was positively associated with age, vaginal birth, and intake of fruit. In contrast, microbial diversity was negatively associated with BMI, processed meats, ready-to-eat meals, sodium, and saturated fat. Our analysis also revealed a correlation between food groups or nutrients and microbial composition. Overall, we provide the first dietary assessment tool to be validated and correlated with microbiome data for population studies.
Ajuts:	Instituto de Salud Carlos III PI17/00614 Instituto de Salud Carlos III PI20/00130 European Commission 812969
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Diet-microbiome relationship ; Relative validation ; Sffq development
Publicat a:	Nutrients, Vol. 13 (august 2021) , ISSN 2072-6643

DOI: 10.3390/nu13092978
PMID: 34578856

17 p, 2.6 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats