Comparing the in vitro efficacy of chlorhexidine and povidone-iodine in the prevention of post-surgical endophthalmitis
Batista, Celso Soares Pereira (Institut d'Investigació Biomèdica Sant Pau)
Loscos-Giménez, Irene (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Gámez, María (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Altaba Sastre, Raúl (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
de Miniac, Daniela (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Martí, Neus (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Bassaganyas Vilarrasa, Francisca (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Juanes Borego, Elena (Institut de Recerca Sant Pau)
Rivera, Alba (Institut de Recerca Sant Pau)
Navarro Risueño, Ferran (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Intravitreal injections are a common ophthalmologic procedure. While infections following these injections are rare, they can lead to endophthalmitis, with potentially serious consequences. Various methods have been proposed to prevent endophthalmitis, including the use of antisepsis and antibiotics in patient preparation. To evaluate the antiseptic efficacy of aqueous chlorhexidine (CHX) and povidone-iodine (PI) when used alone and in combination with lidocaine gel (LG) in vitro. Two independent experimental trials were conducted. The first trial determined the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) of CHX and PI against six bacterial strains. The second trial evaluated the bactericidal efficacy of the antiseptic agents (CHX 0. 1% and PI 5%) and their combination with LG against the same bacterial strains. CHX was more effective than PI in reducing the number of colonies forming units (cfus) of the tested bacteria. The order in which the antiseptic and LG were administered affected their effectiveness, with CHX administered before LG resulting in greater reduction of bacterial growth. Conclusions: CHX 0. 1% is more effective than PI 5% as an antiseptic agent. Application of CHX and PI prior to the use of lidocaine gel results in a more effective reduction of microorganisms.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Chlorhexidine ; Endophthalmitis ; Intravitreal injections ; Povidone-iodine
Published in:	Journal of Ophthalmic Inflammation and Infection, Vol. 14 Núm. 1 (december 2024) , p. 20, ISSN 1869-5760

DOI: 10.1186/s12348-024-00404-2
PMID: 38782819

6 p, 918.5 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles