Reduced H+ channel activity disrupts pH homeostasis and calcification in coccolithophores at low ocean pH
Kottmeier, Dorothee M. (University of Bremen. MARUM Center for Marine Environmental Sciences)
Chrachri, Abdesslam (Marine Biological Association of the United Kingdom)
Langer, Gerald (Marine Biological Association of the United Kingdom)
Helliwell, Katherine E. (Marine Biological Association of the United Kingdom)
Wheeler, Glen (Marine Biological Association of the United Kingdom)
Brownlee, Colin (University of Southampton)

Data:	2022
Resum:	Coccolithophores are major producers of ocean biogenic calcite, but this process is predicted to be negatively affected by future ocean acidification scenarios. Since coccolithophores calcify intracellularly, the mechanisms through which changes in seawater carbonate chemistry affect calcification remain unclear. Here we show that voltage-gated H+ channels in the plasma membrane of Coccolithus braarudii serve to regulate pH and maintain calcification under normal conditions but have greatly reduced activity in cells acclimated to low pH. This disrupts intracellular pH homeostasis and impairs the ability of C. braarudii to remove H+ generated by the calcification process, leading to specific coccolith malformations. These coccolith malformations can be reproduced by pharmacological inhibition of H+ channels. Heavily calcified coccolithophore species such as C. braarudii, which make the major contribution to carbonate export to the deep ocean, have a large intracellular H+ load and are likely to be most vulnerable to future decreases in ocean pH.
Ajuts:	European Commission 670390
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Acidification ; Calcification ; Channels ; Coccolithophore ; Protons ; SDG 14 - Life Below Water
Publicat a:	Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, Issue 19 (May 2022) , art. e2118009119, ISSN 1091-6490

DOI: 10.1073/pnas.2118009119
PMID: 35522711

11 p, 1.7 MB

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