Inflammatory biotype of ADHD is linked to chronic stress : a data-driven analysis of the inflammatory proteome
Schnorr, Isabel (Goethe University Frankfurt)
Siegl, Anne (Goethe University Frankfurt)
Luckhardt, Sonja (Fraunhofer Institute for Translational Medicine and Pharmacology (Frankfurt, Alemanya))
Wenz, Söri (Goethe University Frankfurt)
Friedrichsen, Hendrik (Goethe University Frankfurt)
El Jomaa, Hiba (Goethe University Frankfurt)
Steinmann, Annebirth (Goethe University Frankfurt)
Kilencz, Tünde (Semmelweis University, Department of Psychiatry and Psychotherapy (Budapest, Hungria))
Arteaga-Henriquez, Gara (Hospital Universitari Vall d'Hebron)
Ramos-Sayalero, Carolina (Hospital Universitari Vall d'Hebron)
Ibáñez, Pol (Hospital Universitari Vall d'Hebron)
Rosales, Silvia Karina (Hospital Universitari Vall d'Hebron)
Bitter, István (Semmelweis University, Department of Psychiatry and Psychotherapy (Budapest, Hungria))
Fadeuilhe, Christian (Hospital Universitari Vall d'Hebron)
Ferrer Vinardel, Marc (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Lavebratt, Catharina (Karolinska University Hospital and Karolinska Institutet (Suècia))
Réthelyi, János M. (Semmelweis University, Department of Psychiatry and Psychotherapy (Budapest, Hungria))
Richarte, Vanesa (Hospital Universitari Vall d'Hebron)
Rommelse, Nanda (Semmelweis University, Department of Psychiatry and Psychotherapy (Budapest, Hungria))
Ramos-Quiroga, Josep Antoni (Biomedical Network Research Center on Mental Health , Barcelona, Catalonia Spain)
Arias-Vásquez, Alejandro (Radboud University Medical Center (Nijmegen, Holanda))
Resch, Eduard (Fraunhofer Institute for Translational Medicine and Pharmacology ITMP)
Reif, Andreas (Fraunhofer Institute for Translational Medicine and Pharmacology (Frankfurt, Alemanya))
Matura, Silke (Goethe University Frankfurt)
Schiweck, Carmen (Goethe University Frankfurt)

Data:	2024
Resum:	The association between Attention Deficit Hyperactivity Disorder (ADHD) and low-grade inflammation has been explored in children but rarely in adults. Inflammation is characteristic of some, but not all, patients with ADHD and might be influenced by ADHD medication but also lifestyle factors including nutrition, smoking, and stress. It is also still unclear if any specific symptoms are related to inflammation. Therefore, we assessed 96 inflammatory proteins in a deeply phenotyped cohort of 126 adult ADHD participants with a stable medication status using OLINK technology. A data-based, unsupervised hierarchical clustering method could identify two distinct biotypes within the 126 ADHD participants based on their inflammatory profile: a higher inflammatory potential (HIP) and a lower inflammatory protein potential (LIP) group. Biological processes that differed strongest between groups were related to the NF-κB pathway, chemokine signaling, IL-17 signaling, metabolic alterations, and chemokine attraction. A comparison of sample characteristics revealed that the HIP group was more likely to have higher levels of chronic stress (p < 0. 001), a higher clinical global impression scale score (p = 0. 030), and a higher risk for suicide (p = 0. 032). Medication status did not influence protein levels significantly (p ≥ 0. 074), but psychotropic co-medication (p ≤ 0. 009) did. In conclusion, our data suggest the presence of two distinct biotypes in adults with ADHD. Higher levels of inflammatory proteins in ADHD are linked to higher levels of chronic perceived stress in a linear fashion. Further research on inflammation in adults with ADHD should take stress levels into account.
Ajuts:	European Commission 728018 European Commission 667302 European Commission 964215 European Commission 728018
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	ADHD ; Diagnostic markers ; Human behaviour
Publicat a:	Translational psychiatry, Vol. 14 (january 2024) , ISSN 2158-3188

DOI: 10.1038/s41398-023-02729-3
PMID: 38238292

14 p, 3.8 MB

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