Titers of IgG and IgA against SARS-CoV-2 proteins and their association with symptoms in mild COVID-19 infection
Abril, Andrés G. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Alejandre, Jose (Institut de Recerca Sant Pau)
Mariscal, Anais (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Alserawan, Leticia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Rabella, Núria (Institut d'Investigació Biomèdica Sant Pau)
Roman, Eva (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
López-Contreras, Joaquín (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Navarro Risueño, Ferran (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Serrano, Elena (Institut de Recerca Sant Pau)
Nomdedeu, Josep (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Vidal, Silvia (Institut de Recerca Sant Pau)

Fecha:	2024
Resumen:	Humoral immunity in COVID-19 includes antibodies (Abs) targeting spike (S) and nucleocapsid (N) SARS-CoV-2 proteins. Antibody levels are known to correlate with disease severity, but titers are poorly reported in mild or asymptomatic cases. Here, we analyzed the titers of IgA and IgG against SARS-CoV-2 proteins in samples from 200 unvaccinated Hospital Workers (HWs) with mild COVID-19 at two time points after infection. We analyzed the relationship between Ab titers and patient characteristics, clinical features, and evolution over time. Significant differences in IgG and IgA titers against N, S1 and S2 proteins were found when samples were segregated according to time T1 after infection, seroprevalence at T1, sex and age of HWs and symptoms at infection. We found that IgM + samples had higher titers of IgG against N antigen and IgA against S1 and S2 antigens than IgM − samples. There were significant correlations between anti-S1 and S2 Abs. Interestingly, IgM + patients with dyspnea had lower titers of IgG and IgA against N, S1 and S2 than those without dyspnea. Comparing T1 and T2, we found that IgA against N, S1 and S2 but only IgG against certain Ag decreased significantly. In conclusion, an association was established between Ab titers and the development of infection symptoms.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	COVID-19 ; IgA ; IgG ; SARS-CoV-2 ; Seroprevalence
Publicado en:	Scientific reports, Vol. 14 Núm. 1 (december 2024) , p. 12725, ISSN 2045-2322

DOI: 10.1038/s41598-024-59634-y
PMID: 38830902

12 p, 1.6 MB

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