Oral quinolones versus intravenous β-lactam for the treatment of acute focal bacterial nephritis : a retrospective cohort study
Aceituno, Laia (Universitat Autònoma de Barcelona. Departament de Medicina)
Nuñez-Conde, Andrea (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Serra-Pladevall, Judit (Hospital Universitari de Vic)
Viñado, Belén (Hospital Universitari Vall d'Hebron)
Castellà Fierro, Eva (Hospital Universitari Vall d'Hebron)
Escolà-Vergé, Laura (Institut de Recerca Sant Pau)
Pigrau, Carlos (Hospital Universitari Vall d'Hebron)
Falcó, Vicenç (Hospital Universitari Vall d'Hebron)
Len, Y.O. (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Background: Evidence regarding the best antibiotic regimen and the route of administration to treat acute focal bacterial nephritis (AFBN) is scarce. The aim of the present study was to compare the effectiveness of intravenous (IV) β-lactam antibiotics versus oral quinolones. Methods: This is a retrospective single centre study of patients diagnosed with AFBN between January 2017 and December 2018 in Hospital Universitari Vall d'Hebron, Barcelona (Spain). Patients were identified from the diagnostic codifications database. Patients treated with oral quinolones were compared with those treated with IV β-lactam antibiotics. Therapeutic failure was defined as death, relapse, or evolution to abscess within the first 30 days. Results: A total of 264 patients fulfilled the inclusion criteria. Of those, 103 patients (39%) received oral ciprofloxacin, and 70 (26. 5%) IV β-lactam. The most common isolated microorganism was Escherichia coli (149, 73. 8%) followed by Klebsiella pneumoniae (26, 12. 9%). Mean duration of treatment was 21. 3 days (SD 7. 9). There were no statistical differences regarding therapeutic failure between oral quinolones and IV β-lactam treatment (6. 6% vs. 8. 7%, p = 0. 6). Out of the 66 patients treated with intravenous antibiotics, 4 (6. 1%) experienced an episode of phlebitis and 1 patient (1. 5%) an episode of catheter-related bacteraemia. Conclusions: When susceptible, treatment of AFBN with oral quinolones is as effective as IV β-lactam treatment with fewer adverse events.
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	European journal of clinical microbiology & infectious diseases, 2024 , ISSN 1435-4373

DOI: 10.1007/s10096-024-04871-2
PMID: 38856826

9 p, 982.5 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles