Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life
Cabrerizo, María (Instituto de Salud Carlos III)
Trallero, Gloria (Instituto de Salud Carlos III)
Pena López, María José (Hospital Universitario de Gran Canaria Dr. Negrín)
Cilla, Amaia (Hospital Universitario de Burgos)
Megias, Gregoria (Hospital Universitario de Burgos)
Muñoz-Almagro, Carmen (Hospital Sant Joan de Déu (Esplugues de Llobregat, Catalunya))
Del Amo, Eva (Hospital Sant Joan de Déu (Esplugues de Llobregat, Catalunya))
Roda, Diana (Hospital Sant Joan de Déu (Esplugues de Llobregat, Catalunya))
Mensalvas, Ana Isabel (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Moreno-Docón, Antonio (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
García-Costa, Juan (Complexo Hospitalario Universitario de Ourense - CHUO)
Rabella, Núria (Institut d'Investigació Biomèdica Sant Pau)
Omeñaca, Manuel (Hospital Universitario Miguel Servet (Saragossa))
Romero, María Pilar (Hospital Universitario La Paz (Madrid))
Sanbonmatsu-Gámez, Sara (Hospital Universitario Virgen de las Nieves (Granada))
Pérez-Ruiz, Mercedes (Hospital Universitario Virgen de las Nieves (Granada))
Santos-Muñoz, María José (Hospital Universitario Severo Ochoa)
Calvo, Cristina (Hospital Universitario Severo Ochoa)
Universitat Autònoma de Barcelona

Date:	2015
Abstract:	Human parechoviruses (HPeV) have been recenly recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patients compared with those infected by enterovirus (EV). Infants <1 month with neurological or systemic symptoms were included in a multicentre prospective study. EV and HPeV detection by RT-PCR and genotyping were performed in cerebrospinal fluids (CSF), sera or throat swabs. Out of the total of 84 infants studied during 2013, 32 were EV positive (38 %) and 9 HPeV positive (11 %). HPeV-3 was identified in eight cases and HPeV-5 in one. Mean age of HPeV-positive patients was 18 days. Diagnoses were fever without source (FWS) (67 %), clinical sepsis (22 %) and encephalitis (11 %). Leukocytes in blood and CSF were normal. Pleocytosis (p = 0. 03) and meningitis (p = 0. 001) were significantly more frequent in patients with EV infections than with HPeV. Conclusions: Although HPeV-3 infections were detected less frequently than EV, they still account for approximately 10 % of the cases analysed in infants younger than 1 month. HPeV-3 was mainly associated with FWS and without leukocytosis and pleocytosis in CSF. In these cases, HPeV screening is desirable to identify the aetiologic agent and prevent unnecessary treatment and prolonged hospitalization. What is Known:• Human parechovirus may be a cause of fever and clinical sepsis in the neonatal period. • HPeV-3 might be one of the main agents causing severe neonatal neurological infections. What is New:• This is the first multicenter prospective study focused on newborns and contributes to a better knowledge of these viral infections. Clinical characteristics of enterovirus and parechovirus infections are compared specifically in the neonatal period. • Knowledge of HPeV infections by paediatricians and neonatologists can guide the diagnosis of these patients and avoid unnecessary treatment and prolonged hospitalization.
Note:	This study was partially supported by a grant from the Spanish National Health Institute PI12-00904.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Enterovirus ; Fever ; Human parechovirus ; Neonate ; Sepsis
Published in:	European journal of pediatrics, Vol. 174 Núm. 11 (january 2015) , p. 1511-1516, ISSN 1432-1076

DOI: 10.1007/s00431-015-2566-9
PMID: 25982340

6 p, 223.1 KB

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