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| Home > Articles > Published articles > Mechanisms modulating foam cell formation in the arterial intima : |
(Institut de Recerca Sant Pau) (Institut de Recerca Sant Pau) (Institut de Recerca Sant Pau) (Institut de Recerca Sant Pau) (Institut de Recerca Sant Pau) (Institut de Recerca Sant Pau) (Institut de Recerca Sant Pau)| Date: | 2024 |
| Abstract: | In recent years, the role of macrophages as the primary cell type contributing to foam cell formation and atheroma plaque development has been widely acknowledged. However, it has been long recognized that diffuse intimal thickening (DIM), which precedes the formation of early fatty streaks in humans, primarily consists of lipid-loaded smooth muscle cells (SMCs) and their secreted proteoglycans. Recent studies have further supported the notion that SMCs constitute the majority of foam cells in advanced atherosclerotic plaques. Given that SMCs are a major component of the vascular wall, they serve as a significant source of microvesicles and exosomes, which have the potential to regulate the physiology of other vascular cells. Notably, more than half of the foam cells present in atherosclerotic lesions are of SMC origin. In this review, we describe several mechanisms underlying the formation of intimal foam-like cells in atherosclerotic plaques. Based on these mechanisms, we discuss novel therapeutic approaches that have been developed to regulate the generation of intimal foam-like cells. These innovative strategies hold promise for improving the management of atherosclerosis in the near future. |
| Grants: | Instituto de Salud Carlos III FIS PI21/01523 Instituto de Salud Carlos III FI19/00205 Instituto de Salud Carlos III MV21/00060 Instituto de Salud Carlos III CB16/11/00276 Instituto de Salud Carlos III CB07/08/016 Ministerio de Economía y Competitividad RED2018-102799-T Generalitat de Catalunya 2021 SGR 00834 Ministerio de Ciencia, Innovación y Universidades PID2022-137186OB-100 Agencia Estatal de Investigación RYC-201722879 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Ressenya ; recerca ; Versió publicada |
| Subject: | ApoA1 ; ApoB100 ; ApoC1 ; ApoE ; ApoJ ; Apolipoproteins ; Atherosclerosis ; Cardiovascular diseases ; Foam-like SMC ; Lipoproteins ; Peptidomimetics ; Reverse cholesterol transport ; Transcription factors |
| Published in: | Frontiers in Cardiovascular Medicine, Vol. 11 (2024) , p. 1381520, ISSN 2297-055X |
