Web of Science: 6 cites, Scopus: 5 cites, Google Scholar: cites,
Maternal iron status in early pregnancy and DNA methylation in offspring : an epigenome-wide meta-analysis
Taeubert, M. Jazmin (Heidelberg University Hospital ( Heidelberg, Alemanya))
de Prado-Bert, Paula (Universitat Pompeu Fabra)
Geurtsen, Madelon L. (Erasmus University Medical Center (Rotterdam, Països Baixos))
Mancano, Giulia (University of Bristol (Regne Unit))
Vermeulen, Marijin J. (Erasmus University Rotterdam (Rotterdam, Països Baixos))
Reiss, Irwin Karl Marcel (Erasmus University Rotterdam (Rotterdam, Països Baixos))
Caramaschi, Doretta (University of Exeter (Devon, Regne Unit))
Sunyer Deu, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques)
Sharp, Gemma C. (University of Bristol (Bristol, Regne Unit))
Julvez, Jordi (Institut d'Investigació Sanitària Pere Virgili (Reus, Catalunya))
Muckenthaler, Martina (Heidelberg University Hospital (Heidelberg, Alemanya))
Felix, Janine Frédérique (University Medical Center Rotterdam (Rotterdam, Països Baixos))

Data: 2022
Descripció: 12 pàg.
Resum: Unbalanced iron homeostasis in pregnancy is associated with an increased risk of adverse birth and childhood health outcomes. DNA methylation has been suggested as a potential underlying mechanism linking environmental exposures such as micronutrient status during pregnancy with offspring health. We performed a meta-analysis on the association of maternal early-pregnancy serum ferritin concentrations, as a marker of body iron stores, and cord blood DNA methylation. We included 1286 mother-newborn pairs from two population-based prospective cohorts. Serum ferritin concentrations were measured in early pregnancy. DNA methylation was measured with the Infinium HumanMethylation450 BeadChip (Illumina). We examined epigenome-wide associations of maternal early-pregnancy serum ferritin and cord blood DNA methylation using robust linear regression analyses, with adjustment for confounders and performed fixed-effects meta-analyses. We additionally examined whether associations of any CpGs identified in cord blood persisted in the peripheral blood of older children and explored associations with other markers of maternal iron status. We also examined whether similar findings were present in the association of cord blood serum ferritin concentrations with cord blood DNA methylation. Maternal early-pregnancy serum ferritin concentrations were inversely associated with DNA methylation at two CpGs (cg02806645 and cg06322988) in PRR23A and one CpG (cg04468817) in PRSS22. Associations at two of these CpG sites persisted at each of the follow-up time points in childhood. Cord blood serum ferritin concentrations were not associated with cord blood DNA methylation levels at the three identified CpGs. Maternal early-pregnancy serum ferritin concentrations were associated with lower cord blood DNA methylation levels at three CpGs and these associations partly persisted in older children. Further studies are needed to uncover the role of these CpGs in the underlying mechanisms of the associations of maternal iron status and offspring health outcomes.
Ajuts: Ministerio de Ciencia e Innovación PI11/00610
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Differentially methylated regions ; DNA methylation ; Epigenetics ; Iron metabolism ; Maternal serum ferritin
Publicat a: Clinical Epigenetics, Vol. 14 Núm. 1 (2022) , p. 59, ISSN 1868-7083

DOI: 10.1186/s13148-022-01276-w
PMID: 35505416


12 p, 1.1 MB

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