Evaluating the Quality of Local Programs for Early Detection of Significant Prostate Cancer
Morote Robles, Juan (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Paesano, Nahuel (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Picola, Natàlia (Hospital Universitari de Bellvitge)
Muñoz Rodríguez, José Manuel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Ruiz-Plazas, Xavier (Hospital Universitari Joan XXIII de Tarragona)
Muñoz Rivero, Marta Viridiana (Hospital Universitari Arnau de Vilanova)
Celma, Ana (Hospital Universitari Vall d'Hebron)
García-de Manuel, Gemma (Hospital Universitari de Girona Doctor Josep Trueta)
Abascal, Jose Maria (Parc de Salut MAR de Barcelona)
Servian, Pol (Institut Germans Trias i Pujol)

Date:	2024
Abstract:	Quality control of programs for detection of significant prostate cancer (sPCa) could be defined by the correlation between observed and reference 95% confidence intervals (CIs) for Prostate Imaging-Reporting and Data System (PI-RADS) categories. We used the area under the receiver operating characteristic curve (AUC) for the Barcelona magnetic resonance imaging (MRI) predictive model to screen the quality of ten participant centers in the sPCa opportunistic early detection program in Catalonia. We set an AUC of <0. 8 as the criterion for suboptimal quality. Quality was confirmed in terms of the correlation between actual sPCa detection rates and reference 95% CIs. For a cohort of 2624 men with prostate-specific antigen >3. 0 ng/ml and/or a suspicious digital rectal examination who underwent multiparametric MRI and two- to four-core targeted biopsies of PI-RADS ≥3 lesions and/or 12-core systematic biopsy, AUC values ranged from 0. 527 to 0. 914 and were <0. 8 in four centers (40%). There was concordance between actual sPCa detection rates and reference 95% CIs for one or two PI-RADS categories when the AUC was <0. 8, and for three or four PI-RADS categories when the AUC was ≥0. 8. A review of procedures used for sPCa detection should be recommended in centers with suboptimal quality. Patient summary: We tested a method for assessing quality control for centers carrying out screening for early detection of prostate cancer. We found that the method can identify centers that may need to review their procedures for detection of significant prostate cancer.
Grants:	Instituto de Salud Carlos III PI20/01666
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Clinically significant prostate cancer ; Early detection ; Quality control ; Predictive models
Published in:	European Urology Open Science, Vol. 66 (august 2024) , p. 5-8, ISSN 2666-1683

DOI: 10.1016/j.euros.2024.06.002
PMID: 38988951

4 p, 658.4 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles