Diverse Approaches for the Difunctionalization of PPH Dendrimers, Precise Versus Stochastic : How Does this Influence Catalytic Performance?
Petriccone, Massimo (Universitat Autònoma de Barcelona. Departament de Química)
Laurent, Régis (Centre National de la Recherche Scientifique. Université de Toulouse)
Caminade, Anne-Marie (Centre National de la Recherche Scientifique (França))
Sebastián Pérez, Rosa Maria (Universitat Autònoma de Barcelona. Departament de Química)

Date:	2024
Abstract:	Random difunctionalization of dendrimer surfaces, frequently employed in biological applications, provides the advantage of dual functional groups through a synthetic pathway that is simpler compared to precise difunctionalization. However, is the random difunctionalization as efficient as the precise difunctionalization on the surface of dendrimers? This question is unanswered to date because most dendrimer families face challenges in achieving precise functionalization. Polyphosphorhydrazone (PPH) dendrimers present a unique opportunity to obtain precise difunctionalization at each terminal branching point. The work concerning catalysis we report with PPH dendrimers, whether precisely or randomly functionalized, addresses this question. Across PPH dendrimers, from generations 1 to 3, precise functionalization consistently outperforms random functionalization in terms of efficiency. This finding introduces a novel concept in dendrimer science, emphasizing the superiority of precise over random functionalization methodologies. Introducing a groundbreaking concept in the field of dendrimers.
Grants:	European Commission 860322 Agencia Estatal de Investigación PID2019-106171RB-I00 Agencia Estatal de Investigación PID2020-116844RB-C21 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00064 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00122
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Biological applications ; Branching points ; Catalytic performance ; Difunctionalization ; Functionalizations ; Functionalized ; Simple++ ; Stochastics ; Synthetic pathways ; Terminal branching
Published in:	ACS macro letters, Vol. 13, Issue 7 (July 2024) , p. 853-858, ISSN 2161-1653
Related work:	Petriccone, Massimo; LAURENT, Régis; Sebastian, Rosa Maria; Caminade, Anne-marie, 2024, "Replication data for "Diverse Approaches for the Difunctionalization of PPH Dendrimers, Precise Versus Stochastic: How Does this Influence Catalytic Performance?"", CORA.Repositori de Dades de Recerca https://doi.org/10.34810/data1787

DOI: 10.1021/acsmacrolett.4c00204
PMID: 38917088

6 p, 2.6 MB

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