Association between Reactogenicity and Immunogenicity in a Vaccinated Cohort with Two mRNA SARS-CoV-2 Vaccines at a High-Complexity Reference Hospital : A Post Hoc Analysis on Immunology Aspects of a Prospective Cohort Study
Sáez-Peñataro, Joaquín (Hospital Clínic i Provincial de Barcelona)
Calvo Rojas, Gonzalo (Hospital Clínic i Provincial de Barcelona)
Bascuas, Juan (Hospital Clínic i Provincial de Barcelona)
Mosquera, Maria del Mar (Hospital Clínic i Provincial de Barcelona)
Marcos, María Ángeles (Hospital Clínic i Provincial de Barcelona)
Egri, Natalia (Hospital Clínic i Provincial de Barcelona)
Torres, Ferran (Universitat Autònoma de Barcelona)

Data:	2024
Resum:	Enhancing our comprehension of mRNA vaccines may facilitate the future design of novel vaccines aimed at augmenting immune protection while minimising reactogenic responses. Before this design is carried out, it is important to determine whether adaptive immunity correlates with the reactogenicity profile of vaccines. We studied a large cohort that was vaccinated with mRNA vaccines to answer this question. This was an observational study with real-world data. Reactogenicity data were obtained from the VigilVacCOVID study. Immunogenicity (humoral and cellular) data were retrieved from health records. One main population (n = 215) and two subpopulations were defined (subpopulation 1, n = 3563; subpopulation 2, n = 597). Sensitivity analyses were performed with subpopulations 1 and 2 to explore the consistency of results. We analysed the association of the intensity and types of adverse reactions with the development and quantity of elicited antibody titres. As an exploratory analysis in subpopulation 1, we assessed the association between reactogenicity and cellular immunogenicity. A higher incidence of fever, malaise, and myalgia including severe cases was significantly associated with the development and quantity of positive antibody titres. No significant findings were observed with cellular immunity. We observed a positive association between immunogenicity and reactogenicity. These findings can be relevant for the future development of our understanding of how mRNA vaccines function.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Mrna vaccines ; Reactogenicity ; Immunogenicity ; Pharmacovigilance ; Real-world data
Publicat a:	Vaccines (Basel), Vol. 12 (june 2024) , ISSN 2076-393X

DOI: 10.3390/vaccines12060665
PMID: 38932394

24 p, 1.0 MB

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