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| Pàgina inicial > Articles > Articles publicats > Associations of four biological age markers with child development : |
(Imperial College London. Centre for Environment and Health) (Vytautas Magnus University. Department of Environmental Science) (Institut de Salut Global de Barcelona) (Vytautas Magnus University. Department of Environmental Science) (Norwegian Institute of Public Health) (Universitat Pompeu Fabra) (Institut de Salut Global de Barcelona) (Universitat Pompeu Fabra) (Institut de Salut Global de Barcelona)
| Data: | 2023 |
| Resum: | Background: While biological age in adults is often understood as representing general health and resilience, the conceptual interpretation of accelerated biological age in children and its relationship to development remains unclear. We aimed to clarify the relationship of accelerated biological age, assessed through two established biological age indicators, telomere length and DNA methylation age, and two novel candidate biological age indicators, to child developmental outcomes, including growth and adiposity, cognition, behavior, lung function and the onset of puberty, among European school-age children participating in the HELIX exposome cohort. Methods: The study population included up to 1173 children, aged between 5 and 12 years, from study centres in the UK, France, Spain, Norway, Lithuania, and Greece. Telomere length was measured through qPCR, blood DNA methylation, and gene expression was measured using microarray, and proteins and metabolites were measured by a range of targeted assays. DNA meth-ylation age was assessed using Horvath's skin and blood clock, while novel blood transcriptome and 'immunometabolic' (based on plasma proteins and urinary and serum metabolites) clocks were derived and tested in a subset of children assessed six months after the main follow-up visit. Associations between biological age indicators with child developmental measures as well as health risk factors were estimated using linear regression, adjusted for chronological age, sex, ethnicity, and study centre. The clock derived markers were expressed as Δ age (i. e. predicted minus chronological age). Results: Transcriptome and immunometabolic clocks predicted chronological age well in the test set (r=0. 93 and r=0. 84 respectively). Generally, weak correlations were observed, after adjustment for chronological age, between the biological age indicators. Among associations with health risk factors, higher birthweight was associated with greater immunometabolic Δ age, smoke exposure with greater DNA methylation Δ age, and high family affluence with longer telomere length. Among associations with child developmental measures, all biological age markers were associated with greater BMI and fat mass, and all markers except telomere length were associated with greater height, at least at nominal significance (p<0. 05). Immunometabolic Δ age was associated with better working memory (p=4 e-3) and reduced inattentiveness (p=4 e-4), while DNA methylation Δ age was associated with greater inattentiveness (p=0. 03) and poorer externalizing behaviors (p=0. 01). Shorter telomere length was also associated with poorer externalizing behaviors (p=0. 03). Conclusions: In children, as in adults, biological aging appears to be a multi-faceted process and adiposity is an important correlate of accelerated biological aging. Patterns of associations suggested that accelerated immunometabolic age may be beneficial for some aspects of child development while accelerated DNA methylation age and telomere attrition may reflect early detri-mental aspects of biological aging, apparent even in children. |
| Ajuts: | European Commission 308333 European Commission 874583 Agencia Estatal de Investigación CEX 2018-000806-S Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-595 Generalitat de Catalunya SLT017/20/000119 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Adult ; Aging/genetics ; Biomarkers ; Child ; Child, Preschool ; DNA Methylation ; Epigenesis, Genetic ; Humans ; Infant ; Multiomics ; Obesity/genetics ; Risk Factors ; SDG 3 - Good Health and Well-being |
| Publicat a: | eLife, Vol. 12 (July 2023) , art. e85104, ISSN 2050-084X |
