Correlation between C-reactive protein and the inflammatory ratios in acute schizophrenia inpatients : are they associated?
Llorca-Bofí, Vicent (Institut de Recerca Biomèdica de Lleida)
Bioque, Miquel (Hospital Clínic i Provincial de Barcelona)
Font Font, Maria (Hospital Universitari Arnau de Vilanova)
Gich, Ignasi (Institut d'Investigació Biomèdica Sant Pau)
Mur, Maria (Institut de Recerca Biomèdica de Lleida)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	C-reactive protein (CRP) and inflammatory ratios have been proposed to study immune dysregulation in schizophrenia. Nevertheless, links between CRP and inflammatory ratios in acute SCZ inpatients have been understudied. This study investigated the relationship between CRP and inflammatory ratios (Neutrophil-Lymphocyte Ratio [NRL], Platelet-Lymphocyte Ratio [PLR], Monocyte-Lymphocyte ratio [MLR] and Basophil-Lymphocyte Ratio [BLR]) in a total of 698 acute SCZ inpatients; and analysed how this relationship is affected by sex and type of episode. CRP correlated with NLR (r = 0. 338, p < 0. 001), PLR (r = 0. 271, p < 0. 001) and MLR (r = 0. 148, p < 0. 001) but not with BLR (r = 0. 059, p = 0. 121). Multiple lineal regression analysis showed that high levels of NLR, MLR and PLR but not BLR were independently associated with high CRP levels. No sex-related variations were found. Significant associations were maintained for NLR and MLR in first-episode and multiepisode SCZ, although the strength of the association was stronger in multiepisode SCZ. Again, no sex-related differences were found in these associations. In conclusion, inflammatory ratios were low to moderately associated with CRP in acute SCZ inpatients. NLR and multiepisode SCZ showed the highest associations with CRP. Future studies should consider inflammatory ratios not as a substitute for CRP but as a complementary biomarker.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	C-Reactive Protein ; Inflammatory ratios ; Monocyte-Lymphocyte Ratio ; Neutrophil-Lymphocyte Ratio ; Platelet-Lymphocyte Ratio ; Schizophrenia
Published in:	Journal of Psychiatric Research, Vol. 165 (september 2023) , p. 191-196, ISSN 1879-1379

DOI: 10.1016/j.jpsychires.2023.07.023
PMID: 37515951

6 p, 1.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles