Shuttle-Box memory facilitation by post-training intracranial self-stimulation : Differential effects in rats with high and low basic conditioning levels
Aldavert Vera, Laura (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Segura Torres, Pilar (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Costa Miserachs, David (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Morgado-Bernal, Ignacio (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)

Data:	1996
Resum:	Rats were trained in a two-way active avoidance task (one massed acquisition session of 50 trials) immediately followed by a lateral hypothalamic intracranial self-stimulation (ICSS) treatment. The effects of this ICSS treatment upon retention at different times (24-hours, 7, 15 or 60-days) were studied in independent groups of subjects. Each one of these four groups of subjects was compared with a non-treated one (Control group). All groups of subjects (Control and ICSS) showed a higher performance on the retention session than on the acquisition session. In the Control subjects, the higher retention performances were observed in the 7-days and 15-days groups. However, the ICSS treatment facilitated the 24-hours retention compared to its Control group, allowing the treated subjects to achieve the same level of performance on the 24-hours retention session than that achieved by the non-treated (Control) animals at the 7-days retention test. At the 24-hours retention session, ICSS also increased the percentage of subjects that achieved an established learning criterion and decreased the number of trials to reach it. Clear differences related to the initial level of conditioning (acquisition session) were also observed in the 24-hours groups. That is, the facilitatory ICSS effect was stronger in the subjects with a low level of conditioning and weaker in those with a high level. It is concluded that post-training ICSS accelerates memory consolidation, and may equalize the performance of poor and good learners.
Ajuts:	Ministerio de Educación y Ciencia PB89-0315
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Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Intracranial self-stimulation ; Two-way active avoidance ; Learning and retention ; Memory consolidation processes ; Lateral hypothalamus
Publicat a:	Behavioral Neuroscience, Vol. 110, Núm. 2 (1996) , p. 346-352, ISSN 1939-0084

Postprint 22 p, 217.8 KB

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