Women, lipids, and atherosclerotic cardiovascular disease : a call to action from the European Atherosclerosis Society
Roeters Van Lennep, Jeanine E. (Erasmus Medical Center)
Tokgözoǧlu, Lale S. (Hacettepe University Faculty of Medicine)
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)
Dumanski, Sandra M. (O'Brien Institute for Public Health)
Gulati, Martha (Cedars-Sinai Medical Center)
Hess, Connie N. (Aurora and CPC Clinical Research)
Holven, Kirsten B. (Oslo University Hospital (Oslo, Noruega))
Kavousi, Maryam (University Medical Center Rotterdam (Països Baixos))
Kaylkçloǧlu, Meral (Ege University)
Lutgens, Esther (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Michos, Erin D. (Johns Hopkins University)
Prescott, Eva (Bispebjerg University Hospital)
Stock, Jane K. (European Atherosclerosis Society)
Tybjaerg-Hansen, Anne (University of Copenhagen)
Wermer, Marieke J.H. (University Medical Center Groningen)
Benn, Marianne (University of Copenhagen)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Cardiovascular disease is the leading cause of death in women and men globally, with most due to atherosclerotic cardiovascular disease (ASCVD). Despite progress during the last 30 years, ASCVD mortality is now increasing, with the fastest relative increase in middle-aged women. Missed or delayed diagnosis and undertreatment do not fully explain this burden of disease. Sex-specific factors, such as hypertensive disorders of pregnancy, premature menopause (especially primary ovarian insufficiency), and polycystic ovary syndrome are also relevant, with good evidence that these are associated with greater cardiovascular risk. This position statement from the European Atherosclerosis Society focuses on these factors, as well as sex-specific effects on lipids, including lipoprotein(a), over the life course in women which impact ASCVD risk. Women are also disproportionately impacted (in relative terms) by diabetes, chronic kidney disease, and auto-immune inflammatory disease. All these effects are compounded by sociocultural components related to gender. This panel stresses the need to identify and treat modifiable cardiovascular risk factors earlier in women, especially for those at risk due to sex-specific conditions, to reduce the unacceptably high burden of ASCVD in women.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Atherosclerotic cardiovascular disease ; Cholesterol ; Lipids ; Lipoprotein(a) ; Sex-specific risk ; Triglycerides ; Women
Published in:	European heart journal, Vol. 44 Núm. 39 (14 2023) , p. 4157-4173, ISSN 1522-9645

DOI: 10.1093/eurheartj/ehad472
PMID: 37611089

17 p, 1.8 MB

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