IBD-PODCAST Spain : A Close Look at Current Daily Clinical Practice in IBD Management
Vega, Pablo (Complexo Hospitalario Universitario de Ourense - CHUO)
Huguet, José María (Hospital General Universitario de Valencia)
Gómez, Elena (Hospital Universitario Juan Ramón Jiménez)
Rubio Iturria, Saioa (Hospital Universitario de Navarra)
Suarez, Pablo (Complejo Asistencial Universitario de León)
Vera, Maribel I. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Paredes, José María (Hospital Universitari Doctor Peset (València))
Hernández Camba, Alejandro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Plaza, Rocío (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mañosa i Ciria, Míriam (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes))
Pajares, Ramón (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes))
Sicilia Aladrén, Beatriz (Hospital Universitario de Burgos)
Madero, Lucía (Hospital General Universitari d'Alacant)
Kolterer, Stefanie (AbbVie (Estats Units d'Amèrica))
Leitner, Claudia (AbbVie (Estats Units d'Amèrica))
Heatta-Speicher, Tobias (AbbVie (Estats Units d'Amèrica))
Michelena, Naiara (AbbVie (Estats Units d'Amèrica))
Santos de Lamadrid, Regina (AbbVie (Estats Units d'Amèrica))
Dignass, Axel (Goethe University)
Gomollón, Fernando (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)

Date:	2024
Abstract:	Background: Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) that contributes in part to irreversible bowel damage and long-term complications, reduced quality of life, invalidity, and economic burden. Suboptimal control of IBD is associated with higher healthcare resource utilization (HCRU), impaired quality of life (QoL), and reduced work productivity. Aims: The IBD-PODCAST study aimed to assess the proportion of IBD patients with suboptimal control and its associated impact. Methods: IBD-PODCAST is a cross-sectional, multicenter study that aimed to characterize the CD and UC population with optimal or suboptimal control according to the STRIDE-II criteria and patient- and physician-reported measures. Here we present the results of the Spanish cohort (n = 396). Results: A total of 104/196 (53. 1%) CD and 83/200 (41. 5%) UC patients were found to have suboptimal disease control. Long-term treatment targets according to STRIDE-II were applied in 172 (87. 8%) CD and 181 (90. 5%) UC patients. 125 of 172 (72. 7%) CD and 74 of 181 (40. 9%) UC patients were currently treated with targeted immunomodulators. Patients with CD and UC and suboptimal disease control showed impaired QoL, higher HCRU and direct costs, and also loss of work productivity compared to those with optimal control. Conclusion: Despite a high rate of targeted immunomodulator therapy, a substantial proportion of IBD patients show suboptimal disease control according to the STRIDE II criteria. Those patients with suboptimal disease control exhibit impaired QoL, less work productivity, and higher HCRU, suggesting that there is considerable need for better treatment approaches in IBD.
Note:	Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was funded by AbbVie Spain S.L.U.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Crohn's disease ; Ulcerative colitis ; Inflammatory bowel diseases ; STRIDE II recommendations ; Treat to target strategy
Published in:	Digestive Diseases and Sciences, Vol. 69 Núm. 3 (march 2024) , p. 749-765, ISSN 1573-2568

DOI: 10.1007/s10620-023-08220-9
PMID: 38217680

17 p, 976.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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