Approach to the Epidemiology, Disease Management, and Current Challenges in the Management of Generalized Pustular Psoriasis Through a Survey Conducted Among Spanish Dermatologists Aproximación a la epidemiología, manejo de la enfermedad y retos actuales en la gestión de la psoriasis pustulosa generalizada en España a través de un cuestionario dirigido a dermatólogos
Vilarrasa-Rull, Eva (Universitat Autònoma de Barcelona)
Rivera-Díaz, Raquel (Universidad Complutense de Madrid)
Eiris-Salvado, Noemí (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Carretero-Hernández, Gregorio (Hospital Universitario de Gran Canaria Dr. Negrín)
De la Cueva, Pablo (Hospital Universitario Infanta Leonor)
Carrascosa, José Manuel (Institut Germans Trias i Pujol)

Date:	2024
Abstract:	Background: Generalized pustular psoriasis (GPP) is a rare and severe inflammatory skin disease characterised by recurrent or intermittent flares. Epidemiological and disease management data in Spain are limited. Our goal was to estimate the epidemiology of GPP, explore its management, and reach consensus on the current challenges faced in Spain. Methods: An electronic survey was submitted to dermatologists from the Spanish Academy of Dermatology and Venereology Psoriasis Working Group. This group is experienced in the management of GPP. It included a Delphi consensus to establish the current challenges. Results: A total of 33 dermatologists responded to the survey. A 5-year prevalence and incidence of 13. 05 and 7. 01 cases per million inhabitants, respectively, were estimated. According to respondents, the most common GPP symptoms are pustules, erythema, and desquamation, while 45% of patients present > 1 annual flares. A total of 45% of respondents indicated that flares often require a length of stay between 1 and 2 weeks. In the presence of a flare, 67% of respondents often or always prescribe a non-biological systemic treatment as the first-line therapy [cyclosporine (55%); oral retinoid (30%)], and 45% a biological treatment [anti-TNFα (52%); anti-IL-17 (39%)]. The dermatologists agreed that the main challenges are to define and establish specific therapeutic goals to treat the disease including the patients' perspective on the management of the disease. Conclusion: Our study describes the current situation on the management of GPP in Spain, increasing the present knowledge on the disease, and highlighting the current challenges faced at the moment.
Note:	Los autores quieren agradecer a los miembros del Grupo Español de Psoriasis (GPs) por sus contribuciones al documento y a Outcomes'10 por el apoyo y coordinación metodológica del proyecto
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Castellà
Document:	Article ; recerca ; Versió publicada
Subject:	Psoriasis pustulosa ; Generalizada ; Epidemiología ; Manejo ; Necesidades no cubiertas
Published in:	Actas dermo-sifiliográficas, Vol. 115 Núm. 5 (mayo 2024) , p. 449-457, ISSN 1578-2190

DOI: 10.1016/j.ad.2023.10.022

9 p, 483.5 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles