Prognostic Value of Lymph Node Ratio in Patients with Uterine Carcinosarcoma
Bharathan, Rasiah (Medical University Vienna)
Polterauer, Stephan (Medical University Vienna)
Lopez-Sanclemente, Martha C. (Complejo Hospitalario Torrecárdenas (Almeria))
Trukhan, Hanna (N.N. Alexandrov National Cancer Center)
Pletnev, Andrei (N.N. Alexandrov National Cancer Center)
Heredia, Angel G. (Clinica de Especialidades de la Mujer (Mexico City, Mèxic))
Gil, María M. (Hospital Universitario La Paz (Madrid))
Bakinovskaya, Iria (N.N. Alexandrov National Cancer Center)
Dalamanava, Alena (N.N. Alexandrov National Cancer Center)
Romeo, Margarita (Instituto Catalan de Oncologia Badalona)
Rovski, Dzmitry (N.N. Alexandrov National Cancer Center)
Baquedano, Laura (Hospital Universitario Miguel Servet (Saragossa))
Chiva, Luís (Clínica Universidad de Navarra)
Schwameis, Richard (Medical University Vienna)
Zapardiel, Ignacio (Hospital Universitario La Paz (Madrid))

Fecha:	2024
Resumen:	Uterine carcinosarcoma is a rare high-grade endometrial cancer. Controversy has surrounded a number of aspects in the diagnosis and management of this unique clinicopathological entity, including the efficacy of adjuvant therapy, which has been questioned. An unusual surgico-pathological parameter with prognostic significance in a number of tumour sites is the lymph node ratio (LNR). The availability of data in this respect has been scarce in the literature. The primary aim of this collaborative study was to evaluate the prognostic value of LNR in patients with uterine carcinosarcoma. LNR is a recognized lymph node metric used to stratify prognosis in a variety of malignancies. In this European multinational retrospective study, 93 women with uterine carcinosarcoma were included in the final analysis. We used t-tests and ANOVA for comparison between quantitative variables between the groups, and chi-square tests for qualitative variables. A multivariate analysis using Cox regression analysis was performed to determine potential prognostic factors, including the LNR. Patients were grouped with respect to LNR in terms of 0%, 20% > 0% and >20%. The analysis revealed LNR to be a significant predictor of progression-free survival (HR 1. 69, CI (1. 12-2. 55), p = 0. 012) and overall survival (HR 1. 71, CI (1. 07-2. 7), p = 0. 024). However, LNR did not remain a significant prognostic factor on multivariate analysis. Due to limitations of the retrospective study, a prospective large multinational study, which takes into effect the most recent changes to clinical practice, is warranted to elucidate the value of the pathophysiological metrics of the lymphatic system associated with prognosis.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Uterine ; Carcinosarcoma ; Lymph ; Node ; Ratio ; Prognosis
Publicado en:	Journal of personalized medicine, Vol. 14 Núm. 2 (february 2024) , p. 155, ISSN 2075-4426

DOI: 10.3390/jpm14020155
PMID: 38392588

12 p, 661.5 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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