Urinary Cell Cycle Arrest Biomarkers and Diuretic Efficiency in Acute Heart Failure
Núñez-Marín, Gonzalo (Hospital Clínic Universitari (València))
Romero-González, Gregorio (Institut Germans Trias i Pujol)
Bover, Jordi (Institut Germans Trias i Pujol)
Górriz, Jose Luis (Universitat de València)
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sanchis, Juan (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Núñez, Julio (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
De la Espriella, Rafael (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)

Date:	2024
Abstract:	Introduction: This study aimed to evaluate the association between the NephroCheck® test AKIRisk® score, diuretic efficiency (DE), and the odds of worsening kidney function (WKF) within the first 72 h of admission in patients hospitalized for acute heart failure (AHF). Methods: The study prospectively enrolled 125 patients admitted with AHF. NephroCheck® test was obtained within the first 24 h of admission. DE was defined as net fluid urine output per 40 mg of furosemide equivalents. Results: The median AKIRisk® score was 0. 11 (IQR 0. 06-0. 34), and 38 (30. 4%) patients had an AKIRisk® score >0. 3. The median cumulative DE at 72 h was 1,963 mL (IQR 1317-3,239 mL). At 72 h, a total of 10 (8%) patients developed an absolute increase in sCr =0. 5 mg/dL (WKF). In a multivariable setting, there was an inverse association between the AKIRisk® score and DE within the first 72 h. In fact, the highest the AKIRisk® score (centered at 0. 3), the higher the likelihood of poor DE (below the median) and WKF at 72 h (odds ratio [OR] 2. 04; 95%; CI: 1. 02-4. 07; p = 0. 043, and OR 3. 31, 95% CI: 1. 30-8. 43; p = 0. 012, respectively). Conclusion: In patients with AHF, a higher NephroCheck® AKIRisk® score is associated with poorer DE and a higher risk of WKF at 72 h. Further research is needed to confirm the role of urinary cell cycle arrest biomarkers in the AHF scenario.
Grants:	Instituto de Salud Carlos III PI20/00392
Note:	This work was supported by grants from the Ministry of Economy and Competitiveness, Instituto Carlos III (PI20/00392), CIBER Cardiovascular (16/11/00420 and 16/11/00403), and Heart Failure Association of the Spanish Society of Cardiology (2019).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Diuretic efficiency ; Acute heart failure ; Urinary [TIMP-2]×[IGFBP7]
Published in:	CardioRenal Medicine, Vol. 14 Núm. 1 (17 2024) , p. 261-269, ISSN 1664-5502

DOI: 10.1159/000538774

9 p, 399.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles