Quantitative Microvascular Change Analysis Using a Semi-Automated Software in Macula-off Rhegmatogenous Retinal Detachment Assessed by Swept-Source Optical Coherence Tomography Angiography
Díaz Aljaro, Pablo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Zarranz-Ventura, Javier (Hospital Clínic i Provincial de Barcelona)
Broc Iturralde, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Romanic-Bubalo, Nevena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Díaz-Aljaro, Ignacio (Universidad de Chile)
Chu, Zhongdi (University of Washington)
Wang, Ruikang K. (University of Washington)
Valldeperas, Xavier (Universitat Autònoma de Barcelona. Departament de Cirurgia)

Fecha:	2024
Resumen:	Objective: To analyze the performance of custom semi-automated software for quantitative analysis of retinal capillaries in eyes with macula-off rhegmatogenous retinal detachment (RRD) and the role of these microvascular measures as potential biomarkers of postoperative visual outcomes. Methods: A prospective, observational, and single-center study was conducted on consecutive patients who underwent 25G pars-plana vitrectomy for primary uncomplicated macula-off RRD. Optical coherence tomography angiography (OCTA) was performed in the fellow and RRD eyes before surgery and in months 1, 3, and 6 after surgery. The preoperative values of the fellow eyes were used as surrogates of macula-off ones. The primary endpoints were the mean vessel diameter index (VDI); vessel area density (VAD); and vessel skeleton density (VSD) at month 6. Results: Forty-four eyes (44 patients) were included in the study. Considering the fellow eyes as a surrogate of preoperative values of macula-off eyes, VDI in superficial (SCP) and deep (DCP) capillary plexuses was significantly reduced at month 6 (p = 0. 0087 and p = 0. 0402, respectively); whereas VSD in SCP increased significantly from preoperative values (p = 0. 0278). OCTA built-in software parameters were significantly reduced from month 1 to month 6 in both SCP and DCP (p values ranged between 0. 0235 and <0. 0001). At month 6, 25 (56. 8%) eyes achieved a best-corrected visual acuity BCVA ≥ 0. 3 (LogMAR). The greater the preoperative BCVA, the greater the probability of achieving good visual outcomes (Odds ratio: 11. 06; p = 0. 0037). However, none of the OCTA parameters were associated with the probability of achieving a BCVA improvement ≥ 0. 3. Conclusions: Quantitative evaluation of capillary density and morphology through OCTA and semi-automated software represents a valuable tool for clinical assessment and managing the disease comprehensively.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Rhegmatogenous retinal detachment ; Microvascular changes ; OCTA ; Macula off
Publicado en:	Journal of clinical medicine, Vol. 13 Núm. 10 (may 2024) , ISSN 2077-0383

DOI: 10.3390/jcm13102835
PMID: 38792378

15 p, 2.0 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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