Impact of chronic obstructive pulmonary disease on right ventricular function and remodeling after aortic valve replacement
Myagmardorj, Rinchyenkhand (Leiden University Medical Center)
Stassen, Jan (Leiden University Medical Center)
Nabeta, Takeru (Leiden University Medical Center)
Hirasawa, Kensuke (Leiden University Medical Center)
Singh, Gurpreet K. (Leiden University Medical Center)
van der Kley, Frank (Leiden University Medical Center)
de Weger, Arend (Leiden University Medical Center)
Ajmone Marsan, Nina (Leiden University Medical Center)
Delgado, Victoria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bax, Jeroen J. (Leiden University Medical Center)

Fecha:	2024
Resumen:	Background: Both chronic obstructive pulmonary disease (COPD) and right ventricular (RV) dysfunction are common factors that have been associated with poor prognosis after aortic valve replacement (AVR). Since there is still uncertainty about the impact of COPD on RV function and dilatation in patients undergoing AVR, we sought to explore RV function and remodeling in the presence and absence of COPD as well as their prognostic implications. Methods: Patients who received surgical or transcatheter AVR due to severe AS were screened for COPD. Demographic and clinical data were collected at baseline while echocardiographic measurements were performed at baseline and 1 year after AVR. The study end-point was all-cause mortality. Results: In total 275 patients were included, with 90 (33%) patients having COPD. At 1-year follow-up, mild worsening of tricuspid annular planar systolic excursion and RV dilatation were observed in patients without COPD, while there were significant improvements in RV longitudinal strain, RV wall thickness but dilatation of RV outflow tract distal dimension in the COPD group compared to the baseline. On multivariable analysis, the presence of COPD provided significant incremental prognostic value over RV dysfunction and remodeling. Conclusions: At 1-year after AVR, RV function and dimensions mildly deteriorated in non-COPD group whereas COPD group received significant benefit of AVR in terms of RV function and hypertrophy. COPD was independently associated with >2-fold all-cause mortality and had incremental prognostic value over RV dysfunction and remodeling.
Nota:	Rinchyenkhand Myagmardorj received funding from the European Association of Cardiovascular Imaging (EACVI Training Grant App000073275). K.H. received an ESC Research Grant (R-2018-18,122).
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Aortic valve replacement ; Chronic obstructive pulmonary disease ; Right ventricular function ; Right ventricular remodeling
Publicado en:	International Journal of Cardiology, Vol. 395 (15 2024) , p. 131414, ISSN 1874-1754

DOI: 10.1016/j.ijcard.2023.131414

8 p, 1.4 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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