Corticosterone administration immediately after peripuberty stress exposure does not prevent protracted stress-induced behavioral alterations
Perez-Caballero, Laura (Universitat Autònoma de Barcelona. Institut de Neurociències)
Guillot de Suduiraut, Isabelle (Ecole Polytechnique Fédérale de Lausanne)
Romero, Leire R. (Universitat Autònoma de Barcelona. Institut de Neurociències)
Grosse, Jocelyn (Ecole Polytechnique Fédérale de Lausanne)
Sandi, Carmen (Ecole Polytechnique Fédérale de Lausanne)
Andero Galí, Raül (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)

Fecha:	2024
Resumen:	Stress-related disorders are commonly associated with abnormalities in hypothalamic-pituitary-adrenal (HPA) axis activity. Preliminary studies with cortisol administration in the aftermath of trauma suggest that this HPA axis hormone can potentially prevent maladaptive behavioral and biological stress responses. However, the efficacy of glucocorticoid administration during the peripuberty period has not been tested yet, although this lifetime is a critical time window in brain development and is highly sensitive to the harmful effects of stress. To further examine the short and long-lasting impact of glucocorticoids treatment given during the post-peripubertal stress period, the present study utilized a rat model of peripubertal stress-induced psychopathology and animals were subjected to a battery of tests to assess anxiety-like behaviors, exploratory behavior and reactivity to novelty at late adolescence and sociability, anhedonia and stress coping behaviors at adulthood. All the experiments were performed in males and females to evaluate the potential behavioral sex differences. Overall, our results demonstrated that rats exposed to peripubertal stress show decreased sociability in adulthood without differences in anxiety and depression-like behaviors. Moreover, this study shows that the administration of corticosterone after stress exposure at peripuberty does not prevent stress-induced behavioral alterations. However, we observed that some stress-induced behavioural alterations and corticosterone responses are sex-specific. Thus, the data obtained highlight that delineating sex differences in stress-related studies may ultimately contribute to the development of effective therapeutic interventions for each sex.
Ayudas:	Instituto de Salud Carlos III AC19/00077 Agencia Estatal de Investigación PID2020-112705RB-I00
Nota:	Altres ajuts: acords transformatius de la UAB
Nota:	Altres ajuts: ERA-NET Neuron grant JTC 2019; La Caixa HR22-00737
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Corticosterone ; HPA axis ; Peripubertal stress ; Preventing treatmen ; Sex differences ; Stress
Publicado en:	Psychoneuroendocrinology, Vol. 170 (December 2024) , ISSN 1873-3360
Obra relacionada:	Rodríguez Romero, Leire; Perez-Caballero, Laura; Guillot de Suduiraut, [et al.], 2024, "Replication Data for: Corticosterone administration immediately after peripuberty stress exposure does not prevent protracted stress-induced behavioral alterations", https://doi.org/10.34810/data1738, CORA.Repositori de Dades de Recerca, V1 https://doi.org/10.34810/data1738

DOI: 10.1016/j.psyneuen.2024.107164

10 p, 5.1 MB

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