Obstetric complications and clinical presentation in first episode of psychosis
Valli, Isabel (Hospital Clínic i Provincial de Barcelona)
Garcia Rizo, Clemente (Hospital Clínic i Provincial de Barcelona)
Cuesta, M. (Instituto de Investigación Sanitaria de Navarra)
Vieta, Eduard (Hospital Clínic i Provincial de Barcelona)
Bioque, Miquel (Hospital Clínic i Provincial de Barcelona)
Lobo, Antonio (Instituto de Investigación Sanitaria de Aragón)
González-Pinto, Ana (Arabako Unibertsitate Ospitalea (Vitoria, País Basc))
Pina-Camacho, Laura (Hospital General Universitario Gregorio Marañón)
Corripio, Iluminada (Institut d'Investigació Biomèdica Sant Pau)
Garriga, Marina (Hospital Clínic i Provincial de Barcelona)
Baeza, Inmaculada (Hospital Clínic i Provincial de Barcelona)
Martínez Sadurní, Laura (Institut Hospital del Mar d'Investigacions Mèdiques)
Bitanihirwe, B. (The University of Manchester Humanitarian and Conflict Response Institute)
Cannon, M. (RCSI University of Medicine and Health Science)
Bernardo, Miquel (Hospital Clínic i Provincial de Barcelona)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs. Two-hundred seventy-seven patients with an FEP were assessed for OCs using the Lewis-Murray scale, with data stratified into three subscales depending on the timing and the characteristics of the obstetric event, namely: complications of pregnancy, abnormal foetal growth and development and difficulties in delivery. We also considered other two groups: any complications during the pregnancy period and all OCs taken altogether. Patients were clinically evaluated with the Positive and Negative Syndrome Scale for schizophrenia. Total OCs and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use. Our results highlight the relevance of OCs for the clinical presentation of psychosis. Describing the timing of the OCs is essential in understanding the heterogeneity of the clinical presentation.
Grants:	Ministerio de Ciencia e Innovación PI11/00325 Ministerio de Economía y Competitividad PI14/00612 Instituto de Salud Carlos III PI20/00661
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	First-episode psychosis ; Delivery ; Epiphenomena ; Obstetric complications ; Psychopathology
Published in:	Acta Neuropsychiatrica, Vol. 35 Núm. 3 (february 2023) , p. 156-164, ISSN 1601-5215

DOI: 10.1017/neu.2023.9
PMID: 36861430

9 p, 369.5 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles