Expanded hemodialysis : what's up, Doc?
García-Prieto, Ana (Hospital General Universitario Gregorio Marañón)
de la Flor, José Carlos (Hospital Central de la Defensa Gómez Ulla)
Coll, Elisabet (Institut d'Investigació Biomèdica Sant Pau)
Iglesias-Flores, Eva (Complexo Hospitalario Universitario de Ourense - CHUO)
Reque, Javier (Hospital General Universitario de Castellón)
Valga, Francisco (Hospital Universitario de Gran Canaria Dr. Negrín)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	In recent years there has been an increasing interest in expanded hemodialysis (HDx), an emerging renal replacement therapy based on the use of medium cut-off membranes (MCO). Thanks to the internal architecture of these types of membranes, with a higher pore size and smaller fiber inner diameter to favor internal filtration rate, they can increase the removal of larger middle molecules in conventional hemodialysis. Secondarily, several reports suggest that this therapy potentially improve the outcomes for end-stage renal disease patients. However, HDx has not been defined yet and the characteristics of MCO membranes are not well stablished. The aim of this narrative review is to define HDx and summarize the dialyzers that have been used so far to perform this therapy, collect the evidence available on its efficacy and clinical outcomes compared with other hemodialysis techniques and settle the bases for its optimal prescription.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Chronic hemodialysis ; Dialysis ; Dialysis adequacy ; Haemodialysis ; Uremic toxins
Published in:	Clinical Kidney Journal, Vol. 16 Núm. 7 (january 2023) , p. 1071-1080, ISSN 2048-8513

DOI: 10.1093/ckj/sfad033
PMID: 37398691

10 p, 479.0 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles