Electrophysiological and histological characterization of atrial scarring in a model of isolated atrial myocardial infarction
Amorós Figueras, Gerard (Institut d'Investigació Biomèdica Sant Pau)
Casabella Ramón, Sergi (Institut d'Investigació Biomèdica Sant Pau)
Company-Se, Georgina (Universitat Politècnica de Catalunya)
Arzamendi, Dabit (Institut d'Investigació Biomèdica Sant Pau)
Jorge, Esther (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
García Osuna, Álvaro (Institut d'Investigació Biomèdica Sant Pau)
Macías, Y. (Universidad de Extremadura)
Sánchez-Quintana, D. (Universidad de Extremadura)
Rosell Ferrer, Javier (Universitat Politècnica de Catalunya)
Guerra Ramos, José María (Institut d'Investigació Biomèdica Sant Pau)
Cinca, Juan (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Characterization of atrial myocardial infarction is hampered by the frequent concurrence of ventricular infarction. Theoretically, atrial infarct scarring could be recognized by multifrequency tissue impedance, like in ventricular infarction, but this remains to be proven. Objective: This study aimed at developing a model of atrial infarction to assess the potential of multifrequency impedance to recognize areas of atrial infarct scar. Seven anesthetized pigs were submitted to transcatheter occlusion of atrial coronary branches arising from the left coronary circumflex artery. Six weeks later the animals were anesthetized and underwent atrial voltage mapping and multifrequency impedance recordings. The hearts were thereafter extracted for anatomopathological study. Two additional pigs not submitted to atrial branch occlusion were used as controls. Selective occlusion of the atrial branches induced areas of healed infarction in the left atrium in 6 of the 7 cases. Endocardial mapping of the left atrium showed reduced multi-frequency impedance (Phase angle at 307 kHz: from -17. 1° ± 5. 0° to -8. 9° ± 2. 6°, p <. 01) and low-voltage of bipolar electrograms (. 2 ± 0. 1 mV vs. 1. 9 ± 1. 5 mV vs. , p <. 01) in areas affected by the infarction. Data variability of the impedance phase angle was lower than that of bipolar voltage (coefficient of variability of phase angle at307 kHz vs. bipolar voltage:. 30 vs. 77). Histological analysis excluded the presence of ventricular infarction. Selective occlusion of atrial coronary branches permits to set up a model of selective atrial infarction. Atrial multifrequency impedance mapping allowed recognition of atrial infarct scarring with lesser data variability than local bipolar voltage mapping. Our model may have potential applicability on the study of atrial arrhythmia mechanisms.
Grants:	Ministerio de Economía y Competitividad CB16/11/00276 Instituto de Salud Carlos III PI17/0006
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	ECG ; Anatomopathology ; Atrial branch occlusion ; Atrial myocardial infarction ; Endocardial electrical mapping ; Multifrequency myocardial impedance
Published in:	Frontiers in physiology, Vol. 13 (december 2023) , p. 1104327, ISSN 1664-042X

DOI: 10.3389/fphys.2022.1104327
PMID: 36714312

8 p, 2.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles