Genomic adaptation to small population size and saltwater consumption in the critically endangered Cat Ba langur
Zhang, Liye (German Primate Center. Leibniz Institute for Primate Research)
Leonard, Neahga (Cat Ba National Park)
Passaro, Rick (Cat Ba National Park)
Mai, Sy Luan (Cat Ba National Park)
Pham, van Tuyen (Cat Ba National Park)
Le, Thi Ngoc Han (Cat Ba National Park)
Nguyen, Huy Cam (Cat Ba National Park)
Vogelnest, Larry (Taronga Conservation Society Australia)
Lynch, Michael (Melbourne Zoo)
Fine, Amanda (Wildlife Conservation Society (New York))
Nguyen, Van Long (Wildlife Conservation Society (New York))
Rawson, Benjamin (Wildlife Conservation Society (New York))
Behie, Alison (The Australian National University. School of Archaeology and Anthropology)
Nguyen, Truong (German Primate Center. Leibniz Institute for Primate Research)
Le, Minh D. (Vietnam National University. Central Institute for Natural Resources and Environmental Studies)
Nadler, Tilo (Three Monkeys Wildlife Conservancy)
Walter, Lutz (German Primate Center. Leibniz Institute for Primate Research)
Marquès i Bonet, Tomàs 1975- (Institut Català de Paleontologia Miquel Crusafont)
Hofreiter, Michael (University of Potsdam. Department of Science)
Li, Ming (Chinese Academy of Sciences. Institute of Zoology)
Liu, Zhijin (Capital Normal University (Beijing). College of Life Sciences)
Roos, Christian (German Primate Center. Leibniz Institute for Primate Research)
Nguyen, Thi Thanh Nga (Wildlife Conservation Society (New York))

Data:	2024
Resum:	Many mammal species have declining populations, but the consequences of small population size on the genomic makeup of species remain largely unknown. We investigated the evolutionary history, genetic load and adaptive potential of the Cat Ba langur (Trachypithecus poliocephalus), a primate species endemic to Vietnam's famous Ha Long Bay and with less than 100 living individuals one of the most threatened primates in the world. Using high-coverage whole genome data of four wild individuals, we revealed the Cat Ba langur as sister species to its conspecifics of the northern limestone langur clade and found no evidence for extensive secondary gene flow after their initial separation. Compared to other primates and mammals, the Cat Ba langur showed low levels of genetic diversity, long runs of homozygosity, high levels of inbreeding and an excess of deleterious mutations in homozygous state. On the other hand, genetic diversity has been maintained in protein-coding genes and on the gene-rich human chromosome 19 ortholog, suggesting that the Cat Ba langur retained most of its adaptive potential. The Cat Ba langur also exhibits several unique non-synonymous variants that are related to calcium and sodium metabolism, which may have improved adaptation to high calcium intake and saltwater consumption.
Ajuts:	European Commission 864203 Ministerio de Ciencia, Innovación y Universidades PID2021-126004NB-100 Agencia Estatal de Investigación CEX2018-000792-M Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00177
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Animal physiology ; Evolutionary biology ; Evolutionary ecology ; Evolutionary genetics
Publicat a:	Nature communications, Vol. 15 (2024) , art. 8531, ISSN 2041-1723

DOI: 10.1038/s41467-024-52811-7
PMID: 39358348

14 p, 4.3 MB

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