The Interaction of polygenic susceptibility to stress and childhood adversity dimensions predicts longitudinal trajectories of stress-sensitivity in stress and health
Barrantes Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Gizdic, Alena (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Torrecilla Gonzalez, Pilar (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Mas-Bermejo, Patricia (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals)
Sheinbaum Frank, Tamara (Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (Mèxic))
Papiol, Sergi (Instituto de Salud Carlos III)
Lafit, Ginette (Katholieke Universiteit te Leuven. Department of Neuroscience)
Myin-Germeys, Inez (Katholieke Universiteit te Leuven. Department of Neuroscience)
Rosa de la Cruz, Araceli (Instituto de Salud Carlos III)
Kwapil, Thomas (University of Illinois at Urbana-Champaign. Department of Psychology)

Publicació:	Wiley, 2024
Descripció:	11 pàg.
Resum:	Stress-sensitivity (SS) is considered a psychobiological trait possibly resulting from the interaction of genetic and environmental factors (GxE). This study examined whether the interaction of SS-related genetic markers with interview-based dimensions of childhood adversity predicted longitudinal trajectories of low versus high SS. Participants were nonclinically-ascertained young adults comprising normative and elevated scores on schizotypy. SS trajectories were defined in a previous report based on three prospective assessments (23. 5, 25, 28 years-old) of both retrospective (Perceived Stress Scale; PSS) and momentary (Experience Sampling Methodology; ESM) stress ratings. A total of n = 177 and n = 165 participants with PSS and ESM stress-sensitivity trajectories, respectively, as well as genetic data, were included in the study. GxE effects between a SS Polygenic Risk Score (PRS-SS) and a Genetic Risk Score of the Hypothalamic Pituitary Adrenal axis (GRS-HPA) with childhood adversity dimensions (Intrafamilial Adversity, Threat and Deprivation) on SS trajectories were examined. Threat was the most consistent predictor of persistently high SS. PRS-SS moderated the association of Threat with high-PSS. GRS-HPA moderated the effects of all adversity dimensions on high-PSS. The interaction of PRS-SS with Deprivation and GRS-HPA with Intrafamilial Adversity predicted trajectories of momentary social stress, but the effects were driven by those with lower genetic susceptibility. Genetic-HPA-axis moderates the effects of all adversity dimensions on persistent SS trajectories, as well as PRS-SS and Threat, particularly for retrospective stress measure. The findings highlight the complex interplay between GxE factors and suggest that PSS may better capture SS trait. Including biologically-meaningful GRS indexing SS and adversity dimensions in future studies using comprehensive stress measures would enhance our knowledge on high SS susceptibility and its relationship with diverse psychopathological outcomes.
Ajuts:	Ministerio de Economía y Competitividad PSI2014-54009-R Agencia Estatal de Investigación PSI2017-87512-C2-1-R Agencia Estatal de Investigación PSI2017-87512-C2-2-R Agencia Estatal de Investigación PID2020-119211RB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-01010 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00706
Nota:	Altres ajuts: acords transformatius de la UAB
Nota:	Altres ajuts: Funded by MCIN/AEI 10.13039/501100011033. N. Barrantes-Vidal is supported by the ICREA Acadèmia Research Award (Institució Catalana de Recerca i Estudis Avançats) of the Catalangovernment. A. Gizdic was supported by the Spanish Ministry of Science and Innovation (Grant No. FPU18/04901 (FPU-EST22)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adversity-dimensions ; Gene-environment interactions ; Genetic risk scores ; Longitudinal ; Stress ; Stress-sensitivity ; Trait development
Publicat a:	Stress and Health, Vol. 40, Num. 6 (December 2024) art. e3499, ISSN 1532-3005

DOI: 10.1002/smi.3499
PMID: 39540673

11 p, 688.4 KB

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