Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
Llor, Carl (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Ouchi, Dan (Universitat Autònoma de Barcelona)
Giner-Soriano, Maria (Universitat Autònoma de Barcelona)
Garcia-Sangenis, Ana (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Bjerrum, Lars (University of Copenhagen)
Morros, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)

Fecha:	2021
Resumen:	We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5. 8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with COVID-19 from March to June 2020 and identified all their antibiotic prescriptions in the previous two years. We used a composite severity endpoint, including pneumonia, hospital admission and death due to COVID-19. We examined the influence of high antibiotic exposure (>4 regimens), exposure to highest priority critically important antimicrobials (HPCIA) and recent exposure. Potential confounders were adjusted by logistic regression. A total of 280,679 patients were diagnosed with COVID-19, 146,656 of whom were exposed to at least one antibiotic course (52. 3%) during the preceding two years. A total of 25,222 presented severe COVID-19 infection (9%), and the risk of severity was highest among those exposed to antibiotics (OR 1. 12; 95% CI: 1. 04-1. 21). Among all individuals exposed to antibiotics, high, recent and exposure to HPCIAs were correlated with increased COVID severity (OR 1. 19; 95% CI: 1. 14-1. 26; 1. 41; 95% CI: 1. 36-1. 46; and 1. 35; 95% CI: 1. 30-1. 40, respectively). Our findings confirm a significant correlation between previous antibiotic exposure and increased severity of COVID-19 disease.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Drug resistance ; Microbial ; Primary health care ; COVID-19 ; Anti-bacterial agents
Publicado en:	Antibiotics, Vol. 10 (november 2021) , ISSN 2079-6382

DOI: 10.3390/antibiotics10111364
PMID: 34827302

11 p, 647.6 KB

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