Impact of gestational diabetes mellitus treatment on medium/long-term outcomes after pregnancy : A systematic review and meta-analysis
García-Patterson, Apolonia (Institut d'Investigació Biomèdica Sant Pau)
Balsells, Montserrat
Solà Arnau, Ivan (Institut d'Investigació Biomèdica Sant Pau)
Gich, Ignasi (Institut d'Investigació Biomèdica Sant Pau)
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	We aimed to evaluate the effect of gestational diabetes mellitus (GDM) treatment on medium/long-term outcomes both the mother and offspring. We performed a systematic review on randomized clinical trials addressing specific treatment of women with GDM versus usual care and its impact on maternal and offspring outcomes at medium/long-term. MEDLINE, EMBASE and CENTRAL were searched from inception to 8 October 2021. Outcome variables: maternal (diabetes, metabolic syndrome, 12 secondary); offspring (diabetes, impaired fasting glucose, impaired glucose tolerance, high body mass index, 15 secondary). Risk of bias was assessed with Cochrane tool and aggregation performed with Revman 5. 4. We included five studies (1140 women, 767 offspring) with follow-up ranging 4-16 years after delivery. GDM treatment likely does not reduce risk of maternal diabetes (RR 1. 00; [95% CI 0. 82-1. 23]) and may not reduce that of metabolic syndrome (RR 0. 93; [95% CI 0. 71-1. 22]). We obtained very uncertain evidence that treatment may increase maternal HDL-cholesterol. Findings showed that GDM treatment may not have an impact on infants' outcomes (RRs 0. 79; [95% CI 0. 39-1. 69] for impaired fasting glucose; RR 0. 91; [95% CI 0. 74-1. 12] for body mass index.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Gestational diabetes mellitus ; Long-term ; Mother ; Offspring ; Treatment
Published in:	Diabetic Medicine, Vol. 40 Núm. 1 (january 2023) , p. e14998, ISSN 1464-5491

DOI: 10.1111/dme.14998
PMID: 36326694

11 p, 1.1 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles