Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters : a secondary analysis of the DALI study
Dieberger, Anna Maria (Medical University of Graz (Àustria))
Obermayer-Pietsch, Barbara Maria (Medical University of Graz (Àustrtia))
Harreiter, Jürgen (Medical University of Vienna)
Desoye, Gernot (Medical University of Graz (Àustrtia))
Van Poppel, Mireille (University of Graz (Àustrtia))
Simmons, David Sean (Western Sydney University (Àustrtia))
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Perez, Juan M. Adelantado (Instituto de Salud Carlos III)
Kautzky-Willer, Alexandra (Gender Institute Lapura (Àustrtia))
Damm, Peter P. (University of Copenhagen)
Mathiesen, Elisabeth Reinhardt (University of Copenhagen)
Jensen, Dorte M. (University of Southern Denmark (Països Baixos))
Andersen, Lise-Lotte (University of Southern Denmark (Països Baixos))
Dunne, Fidelma (University of Galway (Escòcia))
Lapolla, Annunziata (Università Degli Studi di Padova (Itàlia))
Dalfra, Maria Grazia (Università Degli Studi di Padova (Itàlia))
Bertolotto, Alessandra (Azienda Ospedaliero Universitaria Pisa (Itàlia))
Jelsma, Judith G. M. (Amsterdam Public Health Research Institute (Països Baixos))
Galjaard, Sander (University Medical Centre Rotterdam (Països Baixos))
Wender-Ozegowska, Ewa (Poznan University of Medical Sciences (Polònia))
Zawiejska, Agnieszka (Poznan University of Medical Sciences (Polònia))
Hill, David J. (Lawson Health Research Institute (Canadà))
Devlieger, Roland (UZ Leuven)
Snoek, Frank (Vrije Universiteit Amsterdam)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Obesity during pregnancy is associated with neonatal adiposity, which is a risk factor for childhood obesity. Maternal physical activity (PA) and sedentary behaviours during pregnancy might modify this risk. We therefore studied associations between maternal PA and sedentary time (ST) during pregnancy and neonatal anthropometry and cord blood parameters and investigated whether associations differed by offspring sex. Participants of the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention (DALI) study with a BMI ≥ 29 kg/m were analysed as a cohort. Maternal moderate-to-vigorous PA (MVPA) and ST were measured repeatedly with accelerometers across pregnancy. Associations between mean levels and changes in MVPA and ST and birthweight, neonatal adiposity (fat mass (FM)%) and cord blood parameters, including C-peptide, leptin and lipids, were analysed in 213 mother-child pairs with Bayesian multilevel models. Interactions with offspring sex were considered. Almost all women decreased MVPA levels and increased ST throughout gestation. Both higher maternal mean MVPA and increasing MVPA were associated with lower offspring FM% in males (-0. 520%; 95% CI: -1. 011%, -0. 031% and -4. 649%; -7. 876%, -1. 432% respectively). In female offspring, mean ST was associated with lower cord blood C-peptide (-0. 145 µg/l; -0. 279 µg/l, -0. 005 µg/l). No associations were found with birthweight or other cord blood parameters. Maternal MVPA is associated with neonatal fat mass, but not birthweight, in male offspring. Our findings underline the importance of physical activity throughout pregnancy.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adiposity ; Bayes Theorem ; Birth Weight ; Body Mass Index ; C-Peptide ; Child ; Exercise ; Female ; Fetal Blood ; Humans ; Infant, Newborn ; Male ; Pediatric Obesity ; Pregnancy ; Sedentary Behavior
Published in:	International journal of obesity, Vol. 47 Núm. 9 (september 2023) , p. 873-881, ISSN 1476-5497

DOI: 10.1038/s41366-023-01347-9
PMID: 37500924

9 p, 1.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles