Rationale, design and organization of the delayed antibiotic prescription (DAP) trial : A randomized controlled trial of the efficacy and safety of delayed antibiotic prescribing strategies in the non-complicated acute respiratory tract infections in general practice
De La Poza Abad, Mariam (Centro de Atención Primaria Doctor Carles Ribas)
Mas Dalmau, Gemma (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Moreno Bakedano, Mikel (Centro de Salud Irutzun)
González González, Ana Isabel (Centro de Salud Vicente Muzas)
Canellas Criado, Yolanda (Centro de Salud Monóvar)
Hernández Anadón, Silvia (Centro de Atención Primaria Jaume I)
Rotaeche Del Campo, Rafael (Grupo de Medicina Basada en la Evidencia de SemFYC)
Torán Montserrat, Pere (Centro de Atención Primaria El Maresme)
Negrete Palma, Antonio (Centro de Atención Primaria El Maresme)
Pera, Guillem (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Borrell-Thió, Eulàlia (Centro de Atención Primaria Sant Roc)
Llor, Carl (Centro de Atención Primaria Jaume I)
Little, Paul (Aldermoor Health Centre)
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2013
Abstract:	Background: Respiratory tract infections are an important burden in primary care and it's known that they are usually self-limited and that antibiotics only alter its course slightly. This together with the alarming increase of bacterial resistance due to increased use of antimicrobials calls for a need to consider strategies to reduce their use. One of these strategies is the delayed prescription of antibiotics. Methods. Multicentric, parallel, randomised controlled trial comparing four antibiotic prescribing strategies in acute non-complicated respiratory tract infections. We will include acute pharyngitis, rhinosinusitis, acute bronchitis and acute exacerbation of chronic bronchitis or chronic obstructive pulmonary disease (mild to moderate). The therapeutic strategies compared are: immediate antibiotic treatment, no antibiotic treatment, and two delayed antibiotic prescribing (DAP) strategies with structured advice to use a course of antibiotics in case of worsening of symptoms or not improving (prescription given to patient or prescription left at the reception of the primary care centre 3 days after the first medical visit). Discussion. Delayed antibiotic prescription has been widely used in Anglo-Saxon countries, however, in Southern Europe there has been little research about this topic. The DAP trial wil evaluate two different delayed strategies in Spain for the main respiratory infections in primary care. Trial registration. This trial is registered with ClinicalTrials. gov, number. © 2013 de la Poza Abad et al. ; licensee BioMed Central Ltd.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Acute bronchitis ; Acute tonsillitis ; Chronic obstructive pulmonary disease ; Delayed antibiotic prescription ; Family medicine ; Pharyngitis ; Respiratory infections ; Rhinosinusitis
Published in:	BMC family practice, Vol. 14 (2013) , p. 63, ISSN 1471-2296

DOI: 10.1186/1471-2296-14-63
PMID: 23682979

7 p, 278.1 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles