Impact of intra-Aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock : Results from the German-Italian-Spanish (GEIST) registry
Santoro, Francesco (University of Foggia)
Núñez Gil, Iván J. (Hospital Clínico San Carlos (Madrid))
Stiermaier, Thomas (University Heart Center Lübeck)
El-Battrawy, Ibrahim (German Center for Cardiovascular Research)
Moeller, Christian (University Heart Center Lübeck)
Guerra, Federico (University Hospital 'Umberto I-Lancisi-Salesi')
Novo, Giuseppina (University of Palermo)
Arcari, Luca (Università degli Studi di Roma "La Sapienza")
Musumeci, Beatrice (Università degli Studi di Roma "La Sapienza")
Cacciotti, Luca (Madre Giuseppina Vannini Hospital)
Mariano, Enrica (University of Rome Tor Vergata)
Romeo, Francesco (University of Rome Tor Vergata)
Cannone, Michele (Bonomo Hospital)
Caldarola, Pasquale (San Paolo Hospital)
Giannini, Irene (German Center for Cardiovascular Research)
Mallardi, Adriana (University of Foggia)
Leopizzi, Alessandra (University of Foggia)
Vitale, Enrica (University of Foggia)
Montisci, Roberta (University of Cagliari)
Meloni, Luigi (University of Cagliari)
Raimondo, Pasquale (Santa Maria Hospital)
Di Biase, Matteo (University of Foggia)
Almendro-Delia, Manuel (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau)
Uribarri, Aitor (Hospital Clínico Universitario (Valladolid))
Akin, Ibrahim (University of Heidelberg)
Thiele, Holger (University of Leipzig and Leipzig Heart Institute)
Eitel, Ingo (University Heart Center Lübeck)
Brunetti, Natale Daniele (University of Foggia)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Takotsubo syndrome (TTS) is an acute and reversible left ventricular dysfunction and can be complicated by cardiogenic shock (CS). However, few data are available on optimal care in TTS complicated by CS. Aim of this study was to evaluate short-and long-Term impact of intra-Aortic balloon pumping (IABP) on mortality in this setting. In a multi-centre, international registry on TTS, 2248 consecutive patients were enrolled from 38 centres from Germany, Italy, and Spain. Of the 2248 patients, 212 (9. 4%) experienced CS. Patients with CS had a higher prevalence of diabetes (27% vs. 19%), male sex (25% vs. 10%), and right ventricular involvement (10% vs. 5%) (P < 0. 01 in all cases). Forty-Three patients with CS (20% of 212) received IABP within 8â h (interquartile range 4-18) after admission. No differences in terms of age, gender, cardiovascular risk factors, and admission left ventricular ejection fraction were found among patients with and without IABP. There were no significant differences in terms of 30-day mortality (16% vs. 17%, P = 0. 98), length of hospitalization (18. 9 vs. 16. 7 days, P = 0. 51), and need of invasive ventilation (35% vs. 41%, P = 0. 60) among two groups: 30-day survival was not significantly different even after propensity score adjustment (log-rank P = 0. 73). At 42-month follow-up, overall mortality in patients with CS and TTS was 35%, not significantly different between patients receiving IABP and not (37% vs. 35%, P = 0. 72). Conclusions: In a large multi-centre observational registry, the use of IABP was not associated with lower mortality rates at short-and long-Term follow-up in patients with TTS and CS.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cardiogenic shock ; GEIST ; IABP ; In-hospital complications ; Intra-aortic balloon counter-pulsation ; Stress cardiomyopathy ; Takotsubo syndrome
Published in:	European Heart Journal Open, Vol. 3 Núm. 1 (january 2023) , p. oead003, ISSN 2752-4191

DOI: 10.1093/ehjopen/oead003
PMID: 36789137

7 p, 731.3 KB

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