Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project
Sánchez, Enric (Universitat de Lleida)
Sánchez, Marta (Universitat de Lleida)
López-Cano, Carolina (Universitat de Lleida)
Bermúdez-López, Marcelino (Instituto de Salud Carlos III)
Valdivielso, José Manuel (Instituto de Salud Carlos III)
Farràs-Sallés, Cristina (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Pamplona, Reinald (Universitat de Lleida)
Torres, Gerard (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
Castro, Eva (Instituto de Salud Carlos III)
Fernández, Elvira (Instituto de Salud Carlos III)
Lecube, Albert (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	There is controversial information about the accumulation of advanced glycation end-products (AGEs) in obesity. We assessed the impact of total and abdominal adiposity on AGE levels via a cross-sectional investigation with 4254 middle-aged subjects from the ILERVAS project. Skin autofluorescence (SAF), a non-invasive assessment of subcutaneous AGEs, was measured. Total adiposity indices (BMI and Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE)) and abdominal adiposity (waist circumference and body roundness index (BRI)) were assessed. Lean mass was estimated using the Hume index. The area under the receiver operating characteristic (ROC) curve was evaluated for each index. Different cardiovascular risk factors (smoking, prediabetes, hypertension and dyslipidemia) were evaluated. In the study population, 26. 2% showed elevated SAF values. No differences in total body fat, visceral adiposity and lean body mass were detected between patients with normal and high SAF values. SAF levels showed a very slight but positive correlation with total body fat percentage (estimated by the CUN-BAE formula) and abdominal adiposity (estimated by the BRI). However, none of them had sufficient power to identify patients with high SAF levels (area under the ROC curve <0. 52 in all cases). Finally, a progressive increase in SAF levels was observed in parallel with cardiovascular risk factors in the entire population and when patients with normal weight, overweight and obesity were evaluated separately. In conclusion, total obesity and visceral adiposity are not associated with a greater deposit of AGE. The elevation of AGE in obesity is related to the presence of cardiometabolic risk.
Ayudas:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-696
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Adipose tissue ; Advanced glycation end-products ; Body composition ; Cardiometabolic risk ; Cardiovascular risk factors ; Novel targets ; Obesity ; Skin autofluorescence
Publicado en:	Nutrients, Vol. 15 Núm. 1 (january 2023) , p. 203, ISSN 2072-6643

DOI: 10.3390/nu15010203
PMID: 36615860

11 p, 902.9 KB

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