Quality of Life and Post-Surgical Complications in Patients on Chronic Antiplatelet Therapy with Proximal Femur Fracture : 12-Month Follow-Up after Implementing a Strategy to Shorten the Time to Surgery
Merchán-Galvis, Angela (Universidad del Cauca)
Anaya, Rafael (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Rodriguez, Mireia (Institut d'Investigació Biomèdica Sant Pau)
Llorca Garcia, Jordi (Xarxa Assitencial Universitària de Manresa)
Castejón, Mercé (Xarxa Assitencial Universitària de Manresa)
Gil Sanchez, José María (Institut d'Investigació Biomèdica Sant Pau)
Millan, Angélica (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Estepa Calvo, Verónica (Hospital Universitari Vall d'Hebron)
Cardona, Elena (Hospital Universitari Vall d'Hebron)
Garcia-Sanchez, Yaiza (Hospital Universitari Vall d'Hebron)
Ruiz Pardos, Ana (Hospital Clínic i Provincial de Barcelona)
Martinez-Zapata, Maria Jose (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	We evaluated a strategy to shorten the time from admission to surgery in patients with proximal femur fractures on chronic antiplatelet therapy. We reported a 12-month follow-up on complications and quality of life (QoL). Multicentre, open-label, randomized, parallel clinical trial. Patients were randomized to either early platelet function-guided surgery (experimental group) or delayed surgery (control group). Medical and surgical complications and QoL (EQ-5D-5L questionnaire) were assessed during the hospital stay, and after hospital discharge at 30 days, and 6 and 12 months. From 156 randomized patients, 143 patients underwent surgery. The mean age was 85. 5 (7. 8) years and 68. 0% were female. After hospital discharge, 5. 7% of patients had surgical wound complications and 55. 9% had medical complications, with 42. 7% having serious adverse events. QoL improved significantly after surgery, with the best scores at the six-month follow-up. The overall mortality was 32. 2%. There were no differences between early and delayed surgery groups in any assessed outcomes. It seems safe to reduce the time of surgery under neuraxial anaesthesia in patients with hip fractures on chronic antiplatelet therapy by platelet function testing. QoL in particular improves in the first six months after surgery.
Grants:	Ministerio de Economía y Competitividad PI16/01879
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Antiplatelet drugs ; Femur fracture ; Randomized clinical trial
Published in:	Journal of clinical medicine, Vol. 12 Núm. 3 (february 2023) , p. 1130, ISSN 2077-0383

DOI: 10.3390/jcm12031130
PMID: 36769778

12 p, 1.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles