Predictors of Local Invasion in Infiltrative Basal Cell Carcinoma : Tumour Budding Outperforms the WHO Subtyping
Fernandez Figueras, Maria Teresa (Universitat Internacional de Catalunya)
Pérez-Muñoz, Noelia (Universitat Internacional de Catalunya)
Puig Sanz, Lluís (Institut de Recerca de Catalunya)
Posada-Caez, Rodolfo (Hospital Universitari General de Catalunya)
Ballester Victoria, Rosa (Hospital Universitari General de Catalunya)
Henriquez, Martha (Universitat Internacional de Catalunya)
Musulén, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Universitat Autònoma de Barcelona

Fecha:	2024
Resumen:	Tumour budding (TB) correlates with increased local invasion in various neoplasms. Certain basal cell carcinomas (BCCs) exhibit local aggressiveness. Detecting adverse prognostic factors in partial biopsies could aid in identifying cases with heightened local risk. The absolute number of TB (≤ 3 tumour cells) in excision specimens of 271 infiltrative BCCs (0: absent; 1: 1-2 foci; 2: ≥ 3 foci; 3: ≥ 10 foci), the histopathological subtype and depth of infiltration, perineural invasion, and other histological features were evaluated. A significant correlation was found between TB and both depth of infiltration (rho 0. 445, p < 0. 001) and perineural invasion (p = 0. 009). In the multivariate analysis of depth and perineural invasion (multiple regression, stepwise), TB was identified as a significant covariate together with diameter, inflammation, and perineural invasion for the former, and depth for the latter. Conversely, no correlation existed between the WHO histological subtypes (infiltrating, sclerosing, and micronodular), and depth of infiltration or perineural invasion. This study demonstrates the value of TB as a biomarker for local invasiveness in BCC. In routine practice, a count of ≥ 3 TB foci in lesions incompletely excised or with narrow tumour-free surgical margins would be a straightforward and reproducible method to guide BCC treatment.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Basal cell carcinoma ; Classification ; Tumor budding ; Tisk assesment ; Treatment ; World Health Organization
Publicado en:	Acta dermato-venereologica, Vol. 104 (2024) , p. adv40172, ISSN 1651-2057

DOI: 10.2340/actadv.v104.40172
PMID: 38956962

6 p, 1.4 MB

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