Immunoaging at Early Ages Could Drive a Higher Comorbidity Burden in People with HIV on Antiretroviral Therapy Compared with the Uninfected Population
Loste, Cora (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Trigueros Peña, Macedonia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Muñoz-López, Francisco (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Martínez, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
González, Sandra (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Puig, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martín Flix, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Bonjoch, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Echeverría, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Date:	2024
Abstract:	This is an observational, cross-sectional, comparative case-control, pilot study aimed at assessing the impact of HIV infection and age on immunological markers in people with HIV (PWH) on antiretroviral therapy (ART). The study included 40 PWH on ART, divided into two age groups (40-45 years vs. ≥60 years), and 30 HIV-uninfected controls matched by sex and age. The results show that older PWH on ART had more comorbidities and a higher frequency of CD8 T cells compared to older controls, with a significant decrease in CD8 naïve T cells with age. Additionally, younger PWH on ART exhibited higher frequencies of activated CD8 T cells and elevated levels of inflammatory markers (sCD14, IL-6) compared to age-matched controls, with values similar to those of older PWH on ART. These findings suggest that younger PWH on ART may experience accelerated immunoaging, highlighting the need for early interventions in this population.
Grants:	Instituto de Salud Carlos III PI19/00947 Agencia Estatal de Investigación PID2020-114929RA-I00 Ministerio de Ciencia e Innovación RYC2020-028934-I
Note:	Altres ajuts: Generalitat de Catalunya (SLT017/20/000095)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	HIV ; Aging ; Inflammaging
Published in:	International journal of molecular sciences, Vol. 25, Num. 20 (october 2024) , ISSN 1422-0067

DOI: 10.3390/ijms252010930
PMID: 39456715

12 p, 1.7 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles