Decreased pre-surgical CD34 +/CD144 + cell number in patients undergoing coronary artery bypass grafting compared to coronary artery disease-free valvular patients
Redondo, Santiago (Hospital Nuestra Señora de Sonsoles (Àvila))
González-Rocafort, Álvaro (Hospital Clínico San Carlos (Madrid))
Navarro-Dorado, Jorge (Universidad Complutense de Madrid)
Ramajo, Marta (Universidad Complutense de Madrid)
Hristov, Mihail (Klinikum der LMU (Munich, Alemanya))
Gordillo-Moscoso, Antonio (Universidad Autónoma de San Luis Potosí (Mèxic))
Reguillo, Fernando (Hospital Clínico San Carlos (Madrid))
Carnero-Alcázar, Manuel (Hospital Clínico San Carlos (Madrid))
Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau)
Rodríguez, Enrique (Hospital Clínico San Carlos (Madrid))
Weber, Christian (Klinikum der LMU (Munich, Alemanya))
Tejerina, Teresa (Universidad Complutense de Madrid)
Universitat Autònoma de Barcelona

Date:	2012
Abstract:	Background: Cardiovascular disease has been linked to endothelial progenitor cell (EPC) depletion and functional impairment in atherosclerosis and aortic stenosis. EPCs may play a pivotal role in vascular grafting. However, the EPC depletion in coronary artery bypass grafting (CABG) patients has not been compared to coronary artery disease-free valvular replacement patients with aortic stenosis. Methods: We aimed to assess the basal number of CD34 /KDR and CD34 /CD144 cells in CABG patients, compared to aortic stenosis valvular replacement patients. 100 patients (51 CABG and 49 valvular surgery ones) were included in the present study. All CABG or valvular patients had angiographic demonstration of the presence or the absence of coronary artery disease, respectively. Numbers of CD34 /KDR and CD34 /CD144 were assessed by flow cytometry of pre-surgical blood samples. Results: We found a lower number of CD34 /CD144 cells in CABG patients compared to valvular patients (0. 21 ± 0. 03% vs. 0. 47 ± 0. 08%), and this difference remained statistically significant after the P was adjusted for multiple comparisons (P = 0. 01428). Both groups had more EPCs than healthy controls. Conclusions: Pre-surgical CD34 /CD144 numbers are decreased in CABG patients, compared to valvular patients with absence of coronary disease. © 2012 Redondo et al; licensee BioMed Central Ltd.
Grants:	Ministerio de Sanidad y Consumo RD06/0014/1007
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cardiac surgery ; Coronary artery disease ; Endothelial progenitor cells
Published in:	Journal of Cardiothoracic Surgery, Vol. 7 Núm. 1 (march 2012) , p. 2, ISSN 1749-8090

DOI: 10.1186/1749-8090-7-2
PMID: 22214418

9 p, 2.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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