Endomyocardial involvement in asymptomatic Latin American migrants with eosinophilia related to helminth infection : A pilot study
Sempere González, Abiu (Hospital Universitari Vall d'Hebron)
Salvador, Fernando (Hospital Universitari Vall d'Hebron)
Milà, Laia (Hospital Universitari Vall d'Hebron)
Casas, Guillem (Hospital Universitari Vall d'Hebron)
Durà-Miralles, Xavier (Hospital Universitari Vall d'Hebron)
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Vila-Olives, Rosa (Hospital Universitari Vall d'Hebron)
Bosch-Nicolau, Pau (Hospital Universitari Vall d'Hebron)
Aznar, Maria Luisa (Hospital Universitari Vall d'Hebron)
Espinosa-Pereiro, Juan (Hospital Universitari Vall d'Hebron)
Treviño Maruri, Begoña (Hospital Universitari Vall d'Hebron)
Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron)
Serre-Delcor, Núria (Hospital Universitari Vall d'Hebron)
Oliveira Souto, Inés (Hospital Universitari Vall d'Hebron)
Pou, Diana (Hospital Universitari Vall d'Hebron)
Rodríguez Palomares, José Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)
Molina Romero, Israel (Hospital Universitari Vall d'Hebron)

Data:	2024
Resum:	Hypereosinophilic syndrome can produce cardiac involvement and endomyocardial fibrosis, which have a poor prognosis. However, there is limited information regarding cardiac involvement among migrants from Latin America with eosinophilia related to helminthiasis. We conducted a pilot observational study where an echocardiography was performed on migrants from Latin America with both eosinophilia (>450 cells/μL) and a diagnosis of helminth infection, and on migrants from Latin America without eosinophilia or helminth infection. Microbiological techniques included a stool microscopic examination using the Ritchie's formalin-ether technique, and a specific serology to detect Strongyloides stercoralis antibodies. 37 participants were included, 20 with eosinophilia and 17 without eosinophilia. Twenty (54. 1%) were men with a mean age of 41. 3 (SD 14. 3) years. Helminthic infections diagnosed in the group with eosinophilia were: 17 cases of S. stercoralis infection, 1 case of hookworm infection, and 2 cases of S. stercoralis and hookworm coinfection. Among participants with eosinophilia, echocardiographic findings revealed a greater right ventricle thickness (p = 0. 001) and left atrial area and volume index (p = 0. 003 and p = 0. 004, respectively), while showing a lower left atrial strain (p = 0. 006) and E-wave deceleration time (p = 0. 008). An increase was shown in both posterior and anterior mitral leaflet thickness (p = 0. 0014 and p = 0. 004, respectively) when compared with participants without eosinophilia. Migrants from Latin America with eosinophilia related to helminthic infections might present incipient echocardiographic alterations suggestive of early diastolic dysfunction, that could be related to eosinophilia-induced changes in the endomyocardium. A recent study in migrants from Sub-Saharan Africa with eosinophilia related to helminth infection describes initial findings on cardiac ultrasound in the form of thickening of the posterior leaflet of the mitral valve, but with no clinical manifestations, representing the early stage of the endomyocardial fibrosis process. The aim of the present study is to evaluate the relationship between eosinophilia secondary to helminth infection and cardiac involvement in Latin American patients. In our cohort, eosinophilia in patients was mainly due to Strongyloides stercoralis infection. Among patients with eosinophilia, echocardiographic findings revealed a greater right ventricle thickness and left atrial area and volume index, while showing a lower left atrial strain and E-wave deceleration time when compared with patients without eosinophilia. These alterations are suggestive of early diastolic dysfunction that could be related to eosinophilia-induced changes in the endomyocardium.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PLoS neglected tropical diseases, Vol. 18 (august 2024) , ISSN 1935-2735

DOI: 10.1371/journal.pntd.0012410
PMID: 39102438

11 p, 424.3 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats