Traditional risk factors and premature acute coronary syndromes in South Eastern Europe : a multinational cohort study
Bugiardini, Raffaele (Università di Bologna)
Cenko, Edina (Università di Bologna)
Yoon, Jinsung (Google Cloud AI)
Bergami, Maria (Università di Bologna)
Vasiljevic, Zorana (University of Belgrade)
Mendieta, Guiomar (Hospital Clínic i Provincial de Barcelona)
Zdravkovic, Marija (University of Belgrade)
Vavlukis, Marija (Ss. Cyril and Methodius University in Skopje)
Kedev, Sasko (Ss. Cyril and Methodius University in Skopje)
Miličić, Davor (University Hospital Center Zagreb)
Badimon, Lina (Institut de Recerca Sant Pau)
Manfrini, Olivia (IRCCS Azienda Ospedaliero-Universitaria di Bologna Sant'Orsola Hospital)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	The age-standardized death rates under 65 years from ischemic heart disease in South Eastern Europe are approximately twice as high than the Western Europe average, but the reasons are not completely recognized. The aim of the present study was to address this issue by collecting and analyzing data from a large, multinational cohort. We enrolled 70,953 Caucasian patients with first acute coronary syndrome, from 36 urban hospital in 7 South Eastern European countries and assessed their life expectancy free of acute coronary syndrome and mortality within 30 days after hospital admission from acute coronary syndrome as estimated in relation to dichotomous categories of traditional risk factors (current smoking, hypertension, diabetes and hypercholesterolemia) stratified according to sex. Compared with patients without any baseline traditional risk factors, the presence of all four risk factors was associated with a 5-year shorter life expectancy free of acute coronary syndrome (women: from 67. 1 ± 12. 0 to 61. 9 ± 10. 3 years; r = -0. 089; p < 0. 001 and men: from 62. 8 ± 12. 2 to 58. 9 ± 9. 9 years; r = -0. 096; p < 0. 001). Premature acute coronary syndrome (women <67 years and men <63 years) was remarkably related to current smoking and hypercholesterolemia among women (RRs: 3. 96; 95% CI: 3. 72-4. 20 and 1. 31; 95% CI: 1. 25-1. 38, respectively) and men (RRs: 2. 82; 95% CI: 2. 71-2. 93 and 1. 39; 95% CI: 1. 34-1. 45, respectively). Diabetes was most strongly associated with death from premature acute coronary syndrome either in women (RR: 1. 52; 95% CI: 1. 29-1. 79) or men (RR: 1. 63; 95% CI: 1. 41-1. 89). Public health policies in South Eastern Europe should place significant emphasis on the four traditional risk factors and the associated lifestyle behaviors to reduce the epidemic of premature ischemic heart disease. Funding: None.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Ischemic heart disease ; Risk factors ; Sex differences
Published in:	The Lancet Regional Health - Europe, Vol. 38 (march 2024) , p. 100824, ISSN 2666-7762

DOI: 10.1016/j.lanepe.2023.100824
PMID: 38476741

13 p, 1.0 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles