Immune-inflammatory effects of the multicomponent intervention FIBROWALK in outdoor and online formats for patients with fibromyalgia
Ferrés, Sònia (Universitat Autònoma de Barcelona. Departament de Psicologia Bàsica, Evolutiva i de l'Educació)
Serrat, Mayte (Hospital Universitari Vall d'Hebron)
Auer, William (Universitat Autònoma de Barcelona. Departament de Psicologia Bàsica, Evolutiva i de l'Educació)
Royuela-Colomer, Estíbaliz (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Almirall, Míriam (Hospital Universitari Vall d'Hebron)
Lizama-Lefno, Andrea (Universidad Autónoma de Chile)
Nijs, Jo (Vrije Universiteit Brussel)
Maes, Michael (Sichuan Provincial Center for Mental Health, University of Electronic Science and Technology of China)
Luciano, Juan Vicente (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Borràs, Xavier (Universitat Autònoma de Barcelona. Departament de Psicologia Bàsica, Evolutiva i de l'Educació)
Feliu-Soler, Albert (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)

Data:	2025
Resum:	The multicomponent intervention FIBROWALK integrates pain science education (PSE), therapeutic exercise, cognitive behavioral therapy (CBT), and mindfulness training for treating fibromyalgia (FM). This study investigated the effects of the FIBROWALK in online (FIBRO-On) and outdoor (FIBRO-Out) formats compared to treatment-as-usual (TAU) on core clinical variables along with serum immune-inflammatory biomarkers and brain-derived neurotrophic factor (BDNF). Furthermore, the predictive value of these biomarkers on clinical response to FIBROWALK was also evaluated. 120 participants were randomly divided into three groups: TAU, TAU + FIBRO-On or TAU + FIBRO-Out. Clinical and blood assessments were conducted pre-post treatment. Both FIBRO-Out and FIBRO-On showed effectiveness (vs TAU) by improving functional impairment and kinesiophobia. Individuals allocated to FIBRO-Out (vs TAU) additionally showed decreases in pain, fatigue, depressive symptoms, and serum IL-6 and IL-10 levels along with IL-6/IL-4 ratio; patients allocated to FIBRO-On only showed a less stepped increase in IL-6 compared to TAU. An exaggerated pro-inflammatory profile along with higher levels of BDNF at baseline predicted greater clinical improvements in both active treatment arms. Our results suggest that FIBROWALK - in online and outdoor formats- is effective in individuals with FM and has significant immune regulatory effects in FM patients, while immune-inflammatory pathways and BDNF levels may in part predict its clinical effectiveness.
Ajuts:	Agencia Estatal de Investigación PID2020-117667RA-I00 Instituto de Salud Carlos III CB06/02/0046 Instituto de Salud Carlos III CB22/02/00052
Nota:	Altres ajuts: acords transformatius de la UAB
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Fibromyalgia ; Multicomponent Intervention ; FIBROWALK ; Online ; Outdoor ; Cytokines ; Brain-derived neurotrophic factor
Publicat a:	Brain, behavior, and immunity, Vol. 125 Núm. 3 (March 2025) , p. 184-197, ISSN 1090-2139

DOI: 10.1016/j.bbi.2024.12.149

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