Factors associated with the discrepancy between objective and subjective cognitive impairment in bipolar disorder
Bonnin, Caterina del Mar (Hospital Clínic i Provincial de Barcelona)
Sánchez-Moreno, Jose (Hospital Clínic i Provincial de Barcelona)
Lima, Flávia M. (Universidade Federal do Rio Grande do Sul)
Roca, Xavier (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Segú, Xavier (Hospital Clínic i Provincial de Barcelona)
Montejo, Laura (Hospital Clínic i Provincial de Barcelona)
Solé, Brisa (Hospital Clínic i Provincial de Barcelona)
Hidalgo-Mazzei, Diego (Hospital Clínic i Provincial de Barcelona)
Martin-Parra, Sara (Hospital Clínic i Provincial de Barcelona)
Martínez-Àran, Anabel (Hospital Clínic i Provincial de Barcelona)
Vieta, Eduard (Hospital Clínic i Provincial de Barcelona)
Torrent, Carla (Hospital Clínic i Provincial de Barcelona)
Rosa, Adriane (Hospital de Clínicas de Porto Alegre (HCPA))
Universitat Autònoma de Barcelona

Data:	2024
Resum:	The aim of this study is to evaluate the discrepancy between objective cognitive measures and cognitive subjective complaints in a sample of euthymic patients with bipolar disorder (BD). Methods: One hundred and sixteen participants (83 euthymic patients with BD and 33 healthy controls) were enrolled for this study. Patients were assessed with a comprehensive neuropsychological battery and they also reported their subjective cognitive complaints with the Cognitive Complaints in Bipolar Disorder Rating Scale (COBRA). The discrepancy between objective and subjective data was calculated using a novel methodology proposed in a previous study (Miskowiak, 2016). Statistical analyses included Pearson correlations and multiple linear regression. Results: Higher number of previous depressive episodes was identified as one variable associated with the global sensitivity composite score (Beta = 0. 25; t = 2. 1; p = 0. 04) and with the verbal learning and memory sensitivity score (Beta = 0. 26; t = 2. 16; p = 0. 03). That is, patients with more previous depressive episodes tend to over-report cognitive complaints. In contrast, higher number of previous hospitalizations was associated with stoicism in the global total score (Beta = -0. 27; t = -2. 24: p = 0. 029) and in the domain of attention/processing speed (Beta = -0. 34; t = -2. 52; p = 0. 016), indicating patients with more hospitalizations tend to report less cognitive complaints. Discussion: Our study identified some factors that might help to explain the discrepancy between objective and subjective cognitive measures in BD, including number of previous depressive episodes and number of previous hospitalizations. This highlights the need of the combined use of both types of cognitive measures to make an accurate assessment of cognitive dysfunctions and their effective treatment.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-01358 Instituto de Salud Carlos III PI17/01066 Instituto de Salud Carlos III PI20/00344
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Attention ; Bipolar Disorder ; Cognitive Dysfunction ; Cyclothymic Disorder ; Humans ; Neuropsychological Tests
Publicat a:	Journal of Affective Disorders, Vol. 349 (15 2024) , p. 210-216, ISSN 1573-2517

DOI: 10.1016/j.jad.2024.01.012
PMID: 38190862

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