Exploring the association between metabolic syndrome, its components and subsequent cancer incidence : A cohort study in Catalonia
López-Jiménez, Tomàs (Universitat Autònoma de Barcelona)
Plana-Ripoll, Oleguer (Aarhus University, Department of Clinical Medicine)
Duarte-Salles, Talita 1985- (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Recalde, Martina (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Bennett, Matthew (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Cos Claramunt, Francesc Xavier (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Puente, Diana (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)

Data:	2024
Resum:	Background: Metabolic syndrome (MS) has emerged as a significant global health concern. The relationship between MS and the risk of cancer doesn't seem clear, whether examining by components or in combination. The objective of this study is to examine the relationship between MS, its components, and the overall risk of cancer, including the risk of 13 specific cancer types. Methods: We included 3,918,781 individuals aged 40 years or older sourced from the SIDIAP database between 2008 and 2017. Cox models were employed with MS components and their combinations. A subsample was created using a matched cohort (by age and sex). Incidence curves were computed to determine the time elapsed between the date of having 1-5 MS components and cancer incidence, compared to matched participants with no MS components, which showed that individuals who had one MS component experienced a greater incidence of cancer over 5 and 10 years than individuals with no MS, and the incidence rose with an increase in the number of MS components. Results: Individuals exposed to MS components were diagnosed with cancer earlier than those who were not exposed to them. In the Cox model, HDL (HR 1. 46, 95% CI: 1. 41-1. 52) and Glycemia (HR 1. 40, 95% CI: 1. 37-1. 44) were the individual combinations with the highest risk of overall cancer. In combinations with two components, the highest HR was HDL+Glycemia (HR 1. 52, 95% CI: 1. 45-1. 59) and Glycemia+HBP (HR 1. 48, 95% CI: 1. 45-1. 50). In combinations with three components, the highest HR was HDL+Glycemia+HBP (HR 1. 58, 95% CI: 1. 55-1. 62). Conclusion: In summary, having one or more MS components raises the risk of developing at least 11 cancer types and these risk differ according to type of component included. Some sex differences are also observed. Our findings suggest that implementing prevention measures aimed at specific MS components may lower the risk of various cancer types.
Ajuts:	Instituto de Salud Carlos III PI17/00914
Nota:	Altres ajuts: World Cancer Research Fund International (2017/1630)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cancer risk factors ; Epidemiology ; Metabolic studies ; Registries
Publicat a:	Cancer Medicine, Vol. 13, Núm. 16 (august 2024) , ISSN 2045-7634

DOI: 10.1002/cam4.7400
PMID: 39149842

14 p, 2.2 MB

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