Comparison of subcutaneous and transdermal administration of buprenorphine for pre-emptive analgesia in dogs undergoing elective ovariohysterectomy
Moll, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Fresno, Laura (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
García Arnas, Félix (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Prandi Chevalier, David (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Andaluz Martínez, Anna (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Data:	2011
Resum:	The clinical efficacy of a 70 μg/h transdermal buprenorphine patch and of 20 μg/kg of buprenorphine administered subcutaneously (SC) for the relief of post-operative pain was determined in 24 healthy female dogs undergoing elective ovariohysterectomy (OHE). Dogs were randomly assigned to three groups: (1) a control group that received no analgesics, (2) a BSC group that received buprenorphine SC (20 μg/kg), and (3) a BP group that received buprenorphine by a 70 μg/h transdermal patch. Dogs were scored for signs of pain at 0, 2, 4, 6, 8, 10, 14, 20, 26, 32 and 38. h after extubation using the Numerical Rating Scale (NRS) and a modified University of Melbourne Pain Scale (UMPS). Mean NRS and UMPS scores for dogs in the BSC group (2. 56 ± 0. 23 and 3. 05 ± 0. 27, respectively) and the BP group (2. 02 ± 0. 24 and 2. 67 ± 0. 23, respectively) were significantly lower (P< 0. 05) compared with dogs in the control group (5. 42 ± 0. 38 and 7. 89 ± 0. 44, respectively), whereas differences between the two buprenorphine treatment groups were not significant. The results indicated that the analgesia produced by the 70 μg/h patch was similar to that induced by SC administration of 20 μg/kg of buprenorphine in dogs undergoing OHE, suggesting that the transdermal buprenorphine patch may be a useful alternative for pain management in dogs.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió sotmesa a revisió
Matèria:	Buprenorphine ; Canine ; Pain ; Subcutaneous ; Transdermal
Publicat a:	The veterinary journal, Vol. 187, Issue 1 (January 2011) , p. 124-128, ISSN 1532-2971

DOI: 10.1016/j.tvjl.2009.11.011

Preprint 26 p, 325.7 KB

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